An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000
An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000
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2000 年人类嗜酸粒细胞性脑膜炎病例爆发后牙买加广州曲霉的流行病学研究
作者：
C. A. Waugh;J. Lindo;J. Lorenzo;R. Robinson
摘要在2000年嗜酸性粒细胞性脑膜炎（EM）大爆发后的5年中，在牙买加的野鼠和软体动物中评估了管圆线虫病的感染状况。对297只鼠、140只褐家鼠和777只陆生软体动物进行了寄生虫学分析，结果表明，在32.0%的鼠和12.5%的软体动物中发现了广州管圆线虫。多因素分析证实A.广州蚜在R. rattus（OR = 1.76），而R. rattus（16·8）显著高于R.褐家鼠（11·3）（Mann-Whitney U检验：P = 0·01）。A.在86种侧耳中检出29%的广州侧耳;五种波特氏菌中有20%;在369只盾壳蟹中，有18.7%在18种盾壳蟹中，有11%在18种盾壳蟹中;在24个veronicellid蛞蝓中占6%。大多数啮齿动物感染发生在牙买加东北部（OR = 11.66），该地区也有大量受感染的软体动物。鉴于A.尽管自2000年爆发以来，大鼠中的广州圆线虫感染显著增加，而且对人类感染的调查显示，在过去15年中至少有10例本地病例，但管圆线虫病仍然是牙买加的一种重要人畜共患病。
SUMMARY The infection status of angiostrongylosis in Jamaica was assessed in wild rats and molluscs in the 5 years following the major outbreak of eosinophilic meningitis (EM) in 2000. Parasitological analyses of 297 Rattus rattus and 140 Rattus norvegicus, and 777 terrestrial molluscs from all 14 Parishes on the island revealed Angiostrongylus cantonensis in 32·0% of the rats and in 12·5% of the molluscs. Multivariate analyses confirmed that A. cantonensis occurred significantly more frequently in R. rattus (Odds Ratio [OR] = 1·76), while mean infection intensity in R. rattus was also significantly higher (16·8) than R. norvegicus (11·3) (Mann–Whitney U-test: P = 0·01). Third-stage larvae of A. cantonensis were detected in 29% of 86 Pleurodonte spp.; in 20% of five Poteria spp.; in 18·7% of 369 Thelidomus asper; in 11% of 18 Sagda spp.; and in 6% of 24 veronicellid slugs. Most rodent infections occurred in Northeastern Jamaica (OR = 11·66), a region where infected molluscs were also abundant. Given the prevalence of A. cantonensis infection in rats has significantly increased since the 2000 outbreak, and that a survey of human infections revealed at least ten autochthonous cases in the last 15 years, angiostrongylosis persists as an important zoonosis in Jamaica.