An anti-c-Fms antibody inhibits orthodontic tooth movement
An anti-c-Fms antibody inhibits orthodontic tooth movement
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DOI：
10.1177/154405910808700405
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发表时间：
2008-04-01
影响因子：
7.6
通讯作者：
Yoshida, N.
中科院分区：
文献类型：
--
作者：
Kitaura, H.;Yoshimatsu, M.;Yoshida, N.
正畸力诱导体内破骨细胞生成。最近有报道，施用抗巨噬细胞集落刺激因子（M-CSF）受体c-Fms的抗体阻断了由肿瘤坏死因子-α（TNF-α）施用诱导的破骨细胞生成和骨侵蚀。本研究旨在检测抗c-Fms抗体对小鼠正畸牙齿移动模型中机械负荷诱导的破骨细胞生成和骨质溶解的影响。使用TNF受体1和2缺陷小鼠，我们发现正畸牙齿移动是由TNF-α介导的。在机械负荷期间，我们每天将抗c-Fms抗体注射到局部部位，持续12天。抗c-Fms抗体显著抑制正畸牙齿移动，显著减少体内破骨细胞的数量，并抑制TNF-α诱导的体外破骨细胞生成。这些结果表明，M-CSF在TNF-α介导的正畸牙齿移动过程中，在机械负荷诱导的破骨细胞生成和骨吸收中起着重要作用。
Orthodontic force induces osteoclastogenesis in vivo. It has recently been reported that administration of an antibody against the macrophage-colony-stimulating factor (M-CSF) receptor c-Fms blocks osteoclastogenesis and bone erosion induced by tumor necrosis factor-alpha (TNF-alpha) administration. This study aimed to examine the effect of an anti-c-Fms antibody on mechanical loading-induced osteoclastogenesis and osteolysis in an orthodontic tooth movement model in mice. Using TNF receptor 1- and 2-deficient mice, we showed that orthodontic tooth movement was mediated by TNF-alpha. We injected anti-c-Fms antibody daily into a local site, for 12 days, during mechanical loading. The anti-c-Fms antibody significantly inhibited orthodontic tooth movement, markedly reduced the number of osteoclasts in vivo, and inhibited TNF-alpha-induced osteoclastogenesis in vitro. These findings suggest that M-CSF plays an important role in mechanical loading-induced osteoclastogenesis and bone resorption during orthodontic tooth movement mediated by TNF-alpha.