New insights into long noncoding RNAs and their roles in glioma.
New insights into long noncoding RNAs and their roles in glioma.
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DOI：
10.1186/s12943-018-0812-2
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发表时间：
2018-02-19
期刊：
影响因子：
37.3
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Peng Z;Liu C;Wu M
胶质瘤是最常见的原发性颅内癌类型之一，具有不同的恶性等级I-IV和组织学亚型，包括星形细胞瘤、多形性胶质母细胞瘤（GBM）、少突胶质细胞瘤和混合瘤。胶质瘤的特征在于快速的细胞增殖和血管生成，并且由于GBM干细胞样细胞（GSC）对常规治疗具有抗性并且容易复发，因此高度恶性且预后差的WHO IV级胶质母细胞瘤占胶质瘤的大多数。因此，探索胶质瘤的确切分子机制和可靠的治疗靶点的研究引起了广泛的关注。基于在胶质瘤组织和细胞系中异常表达的功能性lncRNA的增加，lncRNA可能在胶质瘤的发生、发展和其他恶性表型中起关键作用。本文综述了lncRNA领域的最新进展及其在胶质瘤中的功能作用，并对lncRNA作为新型生物标志物和治疗靶点的潜在临床应用进行了评价。
Glioma is one of the most prevalent types of primary intracranial carcinoma with varying malignancy grades I–IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliomas and mixed tumors. Glioma is characterized by rapid cell proliferation and angiogenesis, and the WHO grade IV glioblastoma, which is highly malignant with poor prognosis because GBM stem-like cells (GSCs) are resistant to conventional therapy and easily recrudescent, accounts for the majority of gliomas. Consequently, investigations exploring the accurate molecular mechanisms and reliable therapeutic targets for gliomas have drawn extensive attention. Based on the increasing amount of functional lncRNAs aberrantly expressed in glioma tissues and cell lines, lncRNAs might be critical for glioma initiation, progression and other malignant phenotypes. This review summarizes the latest insights into the lncRNA field and their functional roles in glioma, therefore evaluating the potential clinical applications of lncRNAs as prospective novel biomarkers and therapeutic targets.
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DOI：
10.1126/science.aal2512
发表时间：
2017-06-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Almeida M;Pintacuda G;Masui O;Koseki Y;Gdula M;Cerase A;Brown D;Mould A;Innocent C;Nakayama M;Schermelleh L;Nesterova TB;Koseki H;Brockdorff N
通讯作者：
Brockdorff N
影响因子：
9.7
作者：
Jia, Peng;Cai, Heng;Xue, Yixue
通讯作者：
Xue, Yixue
影响因子：
16
作者：
Jain AK;Xi Y;McCarthy R;Allton K;Akdemir KC;Patel LR;Aronow B;Lin C;Li W;Yang L;Barton MC
通讯作者：
Barton MC
影响因子：
10.5
作者：
Arun G;Diermeier S;Akerman M;Chang KC;Wilkinson JE;Hearn S;Kim Y;MacLeod AR;Krainer AR;Norton L;Brogi E;Egeblad M;Spector DL
通讯作者：
Spector DL
影响因子：
16.6
作者：
Lagarde J;Uszczynska-Ratajczak B;Santoyo-Lopez J;Gonzalez JM;Tapanari E;Mudge JM;Steward CA;Wilming L;Tanzer A;Howald C;Chrast J;Vela-Boza A;Rueda A;Lopez-Domingo FJ;Dopazo J;Reymond A;Guigó R;Harrow J
通讯作者：
Harrow J