Risk of non-Hodgrkin's lymphoma and exposure to hexachlorocyclohexane, a nested case-control study
Risk of non-Hodgrkin's lymphoma and exposure to hexachlorocyclohexane, a nested case-control study
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DOI：
10.1016/j.ejca.2006.03.035
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发表时间：
2006-11-01
影响因子：
8.4
通讯作者：
Rafnsson, Vilhjalmur
中科院分区：
文献类型：
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作者：
Rafnsson, Vilhjalmur
在流行病学研究中，有机氯与非霍奇金淋巴瘤（NHL）有关。我们阐明了六氯环己烷（一种有机氯杀虫剂）在皮肤接触六氯环己烷个体的NHL病因学中的重要性。这是一项病例对照研究，在一群羊主人中进行，收集了羊浸泡的记录。以浸渍羊的数量作为暴露量的替代物。在研究期间，冰岛没有使用其他杀虫剂。病例（n = 45）通过国家癌症登记处（1962-2003年）的记录联系确定，对照（n = 221）从队列中随机选择。在logistic回归分析中，对于拥有100只或更多羊的个体，与拥有少于100只羊的个体相比，NHL的优势比为3.86 (95% CI 1.59-8.53)，经年龄调整。提示HCH可能与NHL的发生有关。(c) 2006 Elsevier Ltd.版权所有。
Organochlorines have been linked with non-Hodgkin's lymphoma (NHL) in epidemiological studies. we elucidate the importance of hexachlorocyclohexane (HCH), an organochlorine insecticide, in the aetiology of NHL among individuals with dermal exposure to HCH. This is a case-control study nested in a cohort of sheep owners, collected from records on sheep dipping. The number of dipped sheep was used as surrogate for exposure. No other insecticide was used in sheep dip in Iceland during the study period. Cases (n = 45) were identified by record linkage with the national cancer registry (through 1962-2003) and controls (n = 221) were selected at random from the cohort. In logistic regression analysis the odds ratio for NHL was 3.86 (95% CI 1.59-8.53), adjusted for age, for individuals who had 100 sheep or more as compared to those who had less than 100 sheep. The results indicate that HCH may be linked to the development of NHL. (c) 2006 Elsevier Ltd. All rights reserved.