EVOLUTION OF α‐FETOPROTEIN SERUM LEVELS THROUGHOUT LIFE IN HUMANS AND RATS, AND DURING PREGNANCY IN THE RAT *
EVOLUTION OF α‐FETOPROTEIN SERUM LEVELS THROUGHOUT LIFE IN HUMANS AND RATS, AND DURING PREGNANCY IN THE RAT *
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人类和大鼠一生以及大鼠妊娠期间 α-胎蛋白血清水平的演变 *
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
C. Bonet
中科院分区：
文献类型：
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作者：
R. Masseyeff;J. Gilli;B. Krebs;A. Calluaud;C. Bonet
应用人和大鼠甲胎蛋白（AFP）特异性抗血清放射免疫测定法（RIA），研究了人和大鼠AFP水平在一生中的变化。本文测定了66只3-70周龄大鼠、201名健康儿童、192名健康献血员和16名70-98岁老人的血清。对于人类，AFP水平在生命的第一年急剧下降，到第二年末达到较低的基础范围，并在整个成年期保持不变。大鼠也表现出类似的模式，但在生命的每个阶段浓度都较高。大鼠出现青春期时，AFP仍在下降，而人类的成人基础水平在青春期前很久就稳定了。本文研究了29只大鼠的母血AFP，发现其水平在妊娠第10 ~ 13天开始急剧升高。从第13-19天，观察到AFP升高减速，导致第17 - 19天降低。从第19-21天开始，AFP水平再次急剧升高。在妊娠第21天观察到大鼠胎仔数量与母体AFP水平之间存在显著相关性。半子宫切除导致AFP水平下降，与剩余胎儿数量成正比。在整个成年生活中持续存在的AFP的稳定水平归因于这种蛋白质合成的稳定性。相反，在妊娠期，血清AFP曲线的演变取决于胎儿的合成、母体和胎儿的分泌以及胎盘屏障的通透性。
A radioimmunoassay method (RIA) with specific antisera for human and rat alpha fetoprotein (AFP) was used to study the evolution of AFP levels in humans and rats respectively throughout the life span. Sera of 66 rats aged 3-70 weeks as well as sera of 201 clinically well children 192 healthy blood donors and 16 persons aged 70-98 were assayed. In humans AFP levels decreased steeply during the 1st year of life reaching a low basal range by the end of the 2nd year which is maintained throughout adulthood. Rats showed a similar pattern but concentrations were higher at every stage of life. Puberty occurs in rats while AFP is still decreasing whereas in humans the adult basal level is stabilized long before puberty. Maternal serum AFP was studied in 29 rats and the levels were found to begin a sharp increase on the 10th-13th day of gestation. From Day 13-19 a deceleration of AFP increase was observed which led to a decrease between Day 17 and 19. From Day 19-21 AFP levels increased sharply again. A significant correlation was observed on Day 21 of pregnancy between the number of rat fetuses and the maternal AFP level. Hemihysterectomy led to a reduction of AFP level that was grossly proportional to the number of remaining fetuses. The stable level of AFP that persists throughout adult life is attributed to the stability of this proteins synthesis. Conversely in pregnancy the evolution of serum AFP curve is dependent on the fetal synthesis maternal and fetal catabolism and permeability of the placental barrier.