Endothelial Cells
Endothelial Cells
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DOI：
10.1007/978-3-319-57613-8_4
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Sturtzel, Caterina
中科院分区：
文献类型：
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作者：
Sturtzel, Caterina
内皮细胞是心脏和血管系统的组成部分，是心血管系统和免疫系统之间的重要联系。除了它们在血管生成、止血和血管张力调节中被普遍接受的作用外，它们还是免疫反应的重要和活跃成分。一系列先天模式识别受体的表达使它们能够对炎症刺激做出反应，并控制免疫细胞的募集和外渗到全身的靶组织。因此，在本章中，我将总结经典的内皮细胞特性和功能及其与免疫系统的相互作用，以及内皮细胞在促进免疫反应中的操作免疫作用。
Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link between the cardiovascular system and the immune system. Besides their commonly accepted roles in angiogenesis, hemostasis, and the regulation of vascular tone, they are an essential and active component of immune responses. Expression of a range of innate pattern recognition receptors allows them to respond to inflammatory stimulation, and they control immune cell recruitment and extravasation into target tissues throughout the body.In this chapter, I will therefore summarize classical endothelial cell properties and functions and their cross talk with the immune system as well as the operational immunological role of endothelial cells in facilitating immune responses.