Sarcopenic obesity: definition, cause and consequences.
Sarcopenic obesity: definition, cause and consequences.
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DOI：
10.1097/mco.0b013e328312c37d
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发表时间：
2008-11
影响因子：
3.1
通讯作者：
Ferrucci L
中科院分区：
文献类型：
--
作者：
Stenholm S;Harris TB;Rantanen T;Visser M;Kritchevsky SB;Ferrucci L
肌肉质量或力量下降的老年肥胖者有发生不良结局的特殊风险。我们讨论了肥胖个体肌肉损伤的潜在途径，以及关节肥胖和肌肉损伤可能对健康和残疾产生的后果。讨论的重点是是否应该使用低肌肉质量或肌肉无力来定义。过量的能量摄入，缺乏运动，轻度炎症，胰岛素抵抗和激素环境的变化可能导致所谓的“肌肉减少性肥胖”的发展。人们最初认为，与年龄相关的肌肉无力的罪魁祸首是肌肉质量的减少，但现在很清楚，肌肉成分和质量的变化是主要的。我们建议，通过联合考虑肥胖和肌肉力量而不是肥胖和肌肉质量来更好地估计不良结局的风险，如功能受限和死亡率，并且应该重新考虑术语“肌肉减少性肥胖”。识别肥胖患者谁有相关的肌肉问题是临床医生的一个重要目标。需要进一步研究以确定预防和治疗这一重要老年综合征的新靶点。
Older obese persons with decreased muscle mass or strength are at special risk for adverse outcomes. We discuss potential pathways to muscle impairment in obese individuals and the consequences that joint obesity and muscle impairment may have on health and disability. Tantamount to this discussion is whether low muscle mass or, rather, muscle weakness should be used for the definition. Excess energy intake, physical inactivity, low-grade inflammation, insulin resistance and changes in hormonal milieu may lead to the development of so called ‘sarcopenic obesity’. It was originally believed that the culprit of age-related muscle weakness was a reduction in muscle mass, but it is now clear that changes in muscle composition and quality are predominant. We propose that the risk of adverse outcomes, such as functional limitation and mortality, is better estimated by considering jointly obesity and muscle strength rather than obesity and muscle mass and the term “sarcopenic obesity” should be revisited. Recognition of obese patients who have associated muscle problems is an essential goal for clinicians. Further research is needed to identify new target for prevention and cure of this important geriatric syndrome.