Biodegradable Thermomagnetically Responsive Soft Untethered Grippers
Biodegradable Thermomagnetically Responsive Soft Untethered Grippers
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DOI：
10.1021/acsami.8b15646
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发表时间：
2019-01-09
影响因子：
9.5
通讯作者：
Gracias, David H.
中科院分区：
文献类型：
--
作者：
Kobayashi, Kunihiko;Yoon, ChangKyu;Gracias, David H.
软机器人设备，如聚合物微夹持器提供了在难以到达的管道中拾取和放置脆弱生物货物的可能性，其在药物递送、微创手术和生物医学工程中具有潜在的应用。先前，毫米尺寸的自折叠热磁响应软夹持器已经被设计、制造并用于拾取和放置应用，但是存在这样的担忧，即这种装置在人体中的实际临床应用中使用之后可能丢失或遗留。因此，需要制定策略，以确保这些软机器人设备是可生物降解的，以便它们在留在体内时会分解。在本文中，我们描述了由热响应性高溶胀性聚（低聚乙二醇甲醚甲基丙烯酸酯（M-n = 500）-双（2-甲基丙烯酰基）氧乙基二硫化物），P（OEGMA-DSDMA），和低溶胀性聚（丙烯酰胺-N，N '-双（酰基）胱胺）水凝胶组成的双层凝胶，在不受约束的夹具的形状。这些夹持器可以响应于热线索而改变形状，并且由于P（OEGMA-DSDMA）层的温度诱导膨胀而打开和关闭。我们证明，夹持器可以掺杂磁性纳米粒子，使它们可以使用磁场移动或装载化学品作为药物洗脱theragrippers的潜在应用。重要的是，它们在生理体温（类似于37摄氏度）下也是可生物降解的，其基础是通过还原裂解二硫键。这种方法结合了热响应形状变化，磁引导和生物降解性，代表了安全实施无系绳形状变化生物医学设备和医疗和外科应用的软机器人的重大进展。
Soft-robotic devices such as polymeric micro grippers offer the possibility for pick and place of fragile biological cargo in hard-to-reach conduits with potential applications in drug delivery, minimally invasive surgery, and biomedical engineering. Previously, millimeter-sized self folding thermomagnetically responsive soft grippers have been designed, fabricated, and utilized for pick-and-place applications but there is a concern that such devices could get lost or left behind after their utilization in practical clinical applications in the human body. Consequently, strategies need to be developed to ensure that these soft-robotic devices are biodegradable so that they would disintegrate if left behind in the body. In this paper, we describe the photopatterning of bilayer gels composed of a thermally responsive high-swelling poly(oligoethylene glycol methyl ether methacrylate (M-n = 500)-bis(2-methacryloyl)oxyethyl disulfide), P(OEGMA-DSDMA), and a low-swelling poly(acrylamide-N,N'-bis(acyloyl)cystamine) hydrogel, in the shape of untethered grippers. These grippers can change shape in response to thermal cues and open and close due to the temperature-induced swelling of the P(OEGMA-DSDMA) layer. We demonstrate that the grippers can be doped with magnetic nanoparticles so that they can be moved using magnetic fields or loaded with chemicals for potential applications as drug-eluting theragrippers. Importantly, they are also biodegradable at physiological body temperature (similar to 37 degrees C) on the basis of cleavage of disulfide bonds by reduction. This approach that combines thermoresponsive shape change, magnetic guidance, and biodegradability represents a significant advance to the safe implementation of untethered shape-changing biomedical devices and soft robots for medical and surgical applications.