The changes of bone vessels and their role in bone loss in tail-suspended rats
The changes of bone vessels and their role in bone loss in tail-suspended rats
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悬尾大鼠骨血管变化及其在骨丢失中的作用
DOI：
10.1016/j.actaastro.2021.08.031
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发表时间：
2021-12
影响因子：
3.5
通讯作者：
Fan Yu-Bo
中科院分区：
文献类型：
--
作者：
Wang Shou-Hui;Yang Xiao;Ding Dong;Wu Xin-Tong;Han Zhuang;Sun Lian-Wen;Fan Yu-Bo
骨丢失是宇航员长期太空飞行中最高的风险因素之一，可能导致健康问题并增加骨折风险，但其机制仍不清楚。骨是高度血管化的组织，骨内的血管系统在骨的发育、再生和改建中起着重要作用。然而，对于骨骼中血管的变化及其在失重性骨质疏松中的作用还知之甚少，本研究采用尾部悬吊大鼠模型对上述问题进行了研究。结果表明：尾吊大鼠长骨血管体积和血管数增加，H型血管（CD 31 hiEmcnhivesses）减少;运动可减轻尾吊大鼠长骨H型血管的减少和成骨作用。提示骨血管的改变可能是微重力引起骨量快速丢失的主要原因。
Bone loss is one of the highest risk factors during long spaceflight for astronauts which can lead to health problems and increase fracture risk, but the mechanisms are still unclear. Bone is highly vascularized tissue, the vascular system in bone plays an important role in the development, regeneration and remodeling of bone. However, little is known about how the blood vessels in bones change and its effect on microgravity-induced osteoporosis, we investigated the above issues with tail-suspended rat model in this study. The result showed that the blood vessel volume and vessel number in long bones increased and H-type blood vessels (CD31hiEmcnhivessels) reduced; moreover, exercise could alleviate the decrease of H-type blood vessels and osteogenesis in tail-suspended rats. These results revealed that changes of bone blood vessels may be a main reason for microgravity-induced bone mass rapid loss.
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