The Regulation of Contractile Activity in Muscle
The Regulation of Contractile Activity in Muscle
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DOI：
10.1042/bst0070593
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发表时间：
1979-08-01
影响因子：
3.9
通讯作者：
Perry, S. V.
中科院分区：
文献类型：
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作者：
Perry, S. V.
在所有类型的哺乳动物横纹肌中，收缩系统的结构非常相似，这表明转导过程的机制在该组织的不同形式中变化很小。另一方面，对刺激的反应的时间过程是各种肌肉彼此不同的方式之一。事实上，这种反应的模式用于区分构成骨骼肌的两种类型的细胞，即慢纤维和快纤维。由于现在普遍认为收缩是 ATP 水解的结果，因此调节肌原纤维 ATP 酶活性的方式将是决定生理反应性质的最重要因素。因此，不同类型肌肉的收缩反应特征在很大程度上取决于肌原纤维 ATP 酶调节机制的差异。许多因素决定了肌原纤维 ATP 酶的调节方式。这些包括肌肉的神经支配类型、Ca2+ 运输的特性
In all types of mammalian striated muscle the structure of the contractile system is remarkably similar, suggesting that the mechanism of the transduction process varies very little in the different forms of this tissue. On the other hand, the time course of the response to stimulation is one of the ways in which the various kinds of muscle differ from each other. Indeed the pattern of this response is used to distinguish the two types of cell of which skeletal muscle is composed, theslow and fast fibres. As it is now generally agreed that contraction is a consequence of the hydrolysis of ATP, the manner in which the ATPase activity of the myofibril is regulated will be a most important factor in determining the nature of the physiological response. The contractile responses characteristic for different types of muscle will therefore depend largely on the differences in the mechanisms present for regulation of the myofibrillar ATPase. A number of factors determine the way in which myofibrillar ATPase is regulated. These include the type of innervation of the muscle, the properties of the Ca2+-transport