Formation and Reverberation of Sequential Neural Activity Patterns Evoked by Sensory Stimulation Are Enhanced during Cortical Desynchronization
Formation and Reverberation of Sequential Neural Activity Patterns Evoked by Sensory Stimulation Are Enhanced during Cortical Desynchronization
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DOI：
10.1016/j.neuron.2013.06.013
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发表时间：
2013-08-07
期刊：
影响因子：
16.2
通讯作者：
Luczak, Artur
中科院分区：
文献类型：
--
作者：
Contreras, Edgar J. Bermudez;Schjetnan, Andrea Gomez Palacio;Luczak, Artur
据推测，记忆的形成涉及在学习过程中特定事件的神经活动模式的产生以及随后这些模式的自发再激活。在这里，我们提供的证据表明，这些过程也可以在氨基甲酸乙酯麻醉的大鼠中观察到，并且通过捏尾、皮质下碳乙醇输注或全身安非他明引起的非同步脑状态而增强。在去同步过程中，我们发现重复的触觉或听觉刺激在体感和听觉皮层中诱发了独特的连续神经放电模式，这些模式随后在自发活动中再次出现，类似于我们在清醒的动物中观察到的情况。此外，这些模式的形成被NMDA受体拮抗剂阻断，这表明这种现象取决于突触的可塑性。这些结果表明，处于非同步状态的麻醉动物可以作为研究刺激诱导的可塑性的方便模型，以提高我们对大脑中记忆形成和重放的理解。
Memory formation is hypothesized to involve the generation of event-specific neural activity patterns during learning and the subsequent spontaneous reactivation of these patterns. Here, we present evidence that these processes can also be observed in urethane-anesthetized rats and are enhanced by desynchronized brain state evoked by tail pinch, subcortical carbachol infusion, or systemic amphetamine administration. During desynchronization, we found that repeated tactile or auditory stimulation evoked unique sequential patterns of neural firing in somatosensory and auditory cortex and that these patterns then reoccurred during subsequent spontaneous activity, similar to what we have observed in awake animals. Furthermore, the formation of these patterns was blocked by an NMDA receptor antagonist, suggesting that the phenomenon depends on synaptic plasticity. These results suggest that anesthetized animals with a desynchronized brain state could serve as a convenient model for studying stimulus-induced plasticity to improve our understanding of memory formation and replay in the brain.