Validity and reliability of the AD8 informant interview in dementia
Validity and reliability of the AD8 informant interview in dementia
复制标题
DOI：
10.1212/01.wnl.0000247042.15547.eb
复制
发表时间：
2006-12-12
期刊：
影响因子：
9.9
通讯作者：
Morris, John C.
中科院分区：
文献类型：
--
作者：
Galvin, James E.;Roe, Catherine M.;Morris, John C.
目的：在临床样本中建立AD8的效度、信度和判别性。方法：我们评估了255对患者供体。我们将认可的AD8项目数量与独立衍生的临床痴呆评分（CDR）和神经心理测试的表现进行了比较。测定AD8的构效度和并发效度、重测效度、互效度和多式效度以及内部一致性。采用接收算子特征曲线评价AD8的鉴别特性。结果：并发效度较强，AD8评分与CDR相关（r = 0.75, 95% CI 0.63 ~ 0.88）。构念效度检验显示，AD8得分、CDR域与神经心理测试成绩之间存在较强的相关性。AD8的Cronbach alpha为0.84 (95% CI 0.80 ~ 0.87)，表明内部一致性良好。AD8表现出良好的内部可靠性和稳定性（加权kappa = 0.67, 95% CI 0.59 ~ 0.75）。面对面和电话管理均显示出相同的可靠性（加权kappa = 0.65, 95% CI 0.57至0.73）。组间信度非常好（组内相关系数= 0.80,95% CI 0.55 ~ 0.92）。曲线下面积为0.92 (95% CI为0.88 - 0.95)，表明无痴呆个体和认知障碍患者无论病因如何都有很好的区别。结论：AD8是一种简单、灵敏、有效、可靠的区分非痴呆和痴呆个体的方法。它可以作为一种通用的筛查设备来检测认知变化，而不考虑病因和不同类型的信息提供者。
Objective: To establish the validity, reliability, and discriminative properties of the AD8, a brief informant interview to detect dementia, in a clinic sample. Methods: We evaluated 255 patient-informant dyads. We compared the number of endorsed AD8 items with an independently derived Clinical Dementia Rating (CDR) and with performance on neuropsychological tests. Construct and concurrent validity, test-retest, interrater and intermodal reliability, and internal consistency of the AD8 were determined. Receiver operator characteristic curves were used to assess the discriminative properties of the AD8. Results: Concurrent validity was strong with AD8 scores correlating with the CDR (r = 0.75, 95% CI 0.63 to 0.88). Construct validity testing showed strong correlation between AD8 scores, CDR domains, and performance on neuropsychological tests. The Cronbach alpha of the AD8 was 0.84 (95% CI 0.80 to 0.87), suggesting excellent internal consistency. The AD8 demonstrated good intrarater reliability and stability (weighted kappa = 0.67, 95% CI 0.59 to 0.75). Both in-person and phone administration showed equal reliability (weighted kappa = 0.65, 95% CI 0.57 to 0.73). Interrater reliability was very good (Intraclass correlation coefficient = 0.80, 95% CI 0.55 to 0.92). The area under the curve was 0.92 (95% CI 0.88 to 0.95), suggesting excellent discrimination between nondemented individuals and those with cognitive impairment regardless of etiology. Conclusion: The AD8 is a brief, sensitive measure that validly and reliably differentiates between nondemented and demented individuals. It can be used as a general screening device to detect cognitive change regardless of etiology and with different types of informants.