Fueling Clinical and Translational Research in Appalachia: Informatics Platform Approach.
Fueling Clinical and Translational Research in Appalachia: Informatics Platform Approach.
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推动阿巴拉契亚的临床和转化研究：信息学平台方法。
DOI：
10.2196/17962
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发表时间：
2020-10-14
影响因子：
3.2
通讯作者：
Sundaram U
中科院分区：
文献类型：
--
作者：
Cecchetti AA;Bhardwaj N;Murughiyan U;Kothakapu G;Sundaram U
阿巴拉契亚人口是独特的，不仅在文化和地理上，而且在其医疗保健需求，面临着最医疗保健差距在美国。为了满足这些独特的需求，阿巴拉契亚医疗中心需要一个以集中式数据仓库为基础的分析和数据科学工具库，以将医疗保健数据转化为可操作的临床干预措施。然而，这是一个特别具有挑战性的任务，因为阿巴拉契亚内的医疗数据处于碎片化状态，并且需要将其他类型的数据（如环境，社会和经济）与医疗数据整合在一起。本文旨在介绍一个综合平台的结构和过程中，在中级阿巴拉契亚学术医疗中心沿着，随着其最初的用途。阿巴拉契亚信息学平台由阿巴拉契亚临床和转化科学研究所的临床信息学部门开发，由4个主要部分组成：集中式临床数据仓库，建模（统计和机器学习），可视化和模型评估。来自不同临床系统、计费系统和州或国家级数据集的数据被集成到一个集中的数据仓库中。该平台支持研究工作，酌情使用不同的组成部分对数据进行管理和分析。阿巴拉契亚信息学平台是功能性的，并支持了几项研究工作，因为其实施的各种目的，如增加疾病的病理生理学知识，风险识别，风险预测，医疗保健资源利用研究和疾病的经济影响的估计。该平台提供了一种廉价但无缝的方式，将临床和转化研究理念转化为临床应用，适用于资源有限且主要为农村人口的类似阿巴拉契亚的地区。
The Appalachian population is distinct, not just culturally and geographically but also in its health care needs, facing the most health care disparities in the United States. To meet these unique demands, Appalachian medical centers need an arsenal of analytics and data science tools with the foundation of a centralized data warehouse to transform health care data into actionable clinical interventions. However, this is an especially challenging task given the fragmented state of medical data within Appalachia and the need for integration of other types of data such as environmental, social, and economic with medical data. This paper aims to present the structure and process of the development of an integrated platform at a midlevel Appalachian academic medical center along with its initial uses. The Appalachian Informatics Platform was developed by the Appalachian Clinical and Translational Science Institute’s Division of Clinical Informatics and consists of 4 major components: a centralized clinical data warehouse, modeling (statistical and machine learning), visualization, and model evaluation. Data from different clinical systems, billing systems, and state- or national-level data sets were integrated into a centralized data warehouse. The platform supports research efforts by enabling curation and analysis of data using the different components, as appropriate. The Appalachian Informatics Platform is functional and has supported several research efforts since its implementation for a variety of purposes, such as increasing knowledge of the pathophysiology of diseases, risk identification, risk prediction, and health care resource utilization research and estimation of the economic impact of diseases. The platform provides an inexpensive yet seamless way to translate clinical and translational research ideas into clinical applications for regions similar to Appalachia that have limited resources and a largely rural population.
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