Plant-derived Monoclonal Antibodies as Human Biologics for Infectious Disease and Cancer
Plant-derived Monoclonal Antibodies as Human Biologics for Infectious Disease and Cancer
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DOI：
10.1079/9781780643434.0042
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Lai, Huafang
中科院分区：
文献类型：
--
作者：
Chen, Qiang;Lai, Huafang
本章重点介绍了植物作为一种创新、快速、灵活和经济的系统，用于开发和生产基于单克隆抗体（MAb）的人类生物制剂，用于治疗传染病和癌症的重要性。最近的发展解构病毒为基础的载体，允许快速和高水平的单克隆抗体在植物中的瞬时表达。植物糖工程的进展，使植物产生单克隆抗体具有上级的功效和安全性比其他传统系统的描述和这些新的突破，这促进了植物表达系统的综合优势，成为商业开发和生产人类生物制品的首要平台，讨论了几个领先的单克隆抗体为基础的生物制品。
This chapter focuses on the importance of plants as an innovative, speedy, flexible and economical system for developing and producing monoclonal antibody (MAb)-based human biologics for infectious disease and cancer. The recent development of deconstructed virus-based vectors that have allowed rapid and high-level transient expression of MAbs in plants is presented. The progress in plant glycoengineering that allows plants to produce MAbs with superior efficacy and safety than other traditional systems is described and the combined advantages of these new breakthroughs, which have promoted the plant expression system to become a premier platform for the commercial development and production of human biologics, are discussed in the context of several leading MAb-based biologics.