Poor postoperative blood glucose control increases surgical site infections after surgery for hepato-biliary-pancreatic cancer: a prospective study in a high-volume institute in Japan
Poor postoperative blood glucose control increases surgical site infections after surgery for hepato-biliary-pancreatic cancer: a prospective study in a high-volume institute in Japan
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DOI：
10.1016/j.jhin.2007.12.002
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发表时间：
2008-03-01
影响因子：
6.9
通讯作者：
Miyazaki, M.
中科院分区：
文献类型：
--
作者：
Ambiru, S.;Kato, A.;Miyazaki, M.
前瞻性观察了265名等待肝-胆-胰腺手术的患者的手术部位感染。SSI发生率因肝胆胰术式不同而不同。多变量分析确定肠吻合、术后血糖控制不佳和癌症类型是独立的危险因素。SSI发生率与术后期间出现的高血糖程度直接相关。特别是，在通过胰岛素输注治疗将血糖维持在200 mg/dL的患者中，SSI的发生率为5/25(20%)，明显好于在胰岛素输注治疗后血糖未维持在200 mg/dL的患者中的49/94(52%)(P<；0.01)。为了减少SSI发生率，术后血糖维持在200 mg/dL是必要的。(C)2008年医院感染学会。爱思唯尔有限公司出版。保留所有权利。
Two hundred and sixty-five consecutive patients awaiting hepato-biliary-pancreatic surgery were prospectively observed for surgical site infections (SSIs). SSI rates differed according to type of hepato-biliary-pancreatic surgery. Multivariate analysis identified enteric anastomoses, poor postoperative blood glucose control and type of cancer as independent risk factors. SSI rates were directly correlated with the degree of hyperglycaemia encountered during the postoperative period. In particular, SSI rates were 5/25 (20%) among patients in whom a blood glucose level of < 200 mg/dL was maintained by insulin infusion therapy, which was significantly better than the rates of 49/94 (52%) among patients in whom a blood glucose level of < 200 mg/dL was not maintained despite insulin infusion therapy (P < 0.01). It is necessary to maintain postoperative blood glucose levels of < 200 mg/dL in order to reduce SSI rates. (c) 2008 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.