Reproduction regulates Drosophila nutrient intake through independent effects of egg production and sex peptide: Implications for aging.
Reproduction regulates Drosophila nutrient intake through independent effects of egg production and sex peptide: Implications for aging.
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DOI：
10.3233/nha-1613
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发表时间：
2016-10-27
影响因子：
--
通讯作者：
Tatar M
中科院分区：
文献类型：
--
作者：
Bowman E;Tatar M
背景技术背景：蛋白质与碳水化合物的比例（P：C）会影响生殖和寿命，这些结果通常通过不同的P：C摄入量来最大化。目的：确定雌性果蝇的生殖是否会导致P：C摄入量增加。区分这种偏好是由卵子产生还是由精液中男性来源的性肽驱动。方法：在饮食选择试验中测量蛋白质和碳水化合物的摄入量。计算了交配和未交配的可育雌性、交配和未交配的不育雌性以及与野生型雄性和缺乏性肽的雄性交配的两种类型雌性的大量营养素摄入量。结果：交配的女性有较高的P：C摄入量相对于未交配的女性和交配，不育的女性。与野生型雄性和缺乏性肽的雄性交配的可育雌性具有高P：C摄入量，但不育雌性在未交配时和与缺乏性肽的雄性交配时具有相似的低P：C摄入量。结论：产卵和性肽的代谢需求单独足以驱动成年雌性果蝇的P：C摄入量升高。因此，生殖状态可以调节动物如何消耗大量营养素，这反过来又会影响它们的健康和衰老。
BACKGROUND: The ratio of protein to carbohydrate (P:C) consumed influences reproduction and lifespan, outcomes that are often maximized by different P:C intake. OBJECTIVE: Determine if reproduction in female Drosophila drives elevated P:C intake. Distinguish whether such a preference is driven by egg production or from male-derived sex peptides in seminal fluid. METHODS: Intake of protein and carbohydrate was measured in a diet-choice assay. Macronutrient intake was calculated for mated and unmated fertile females, mated and unmated sterile females, and both types of female when mated to wildtype males and to males lacking sex peptide. RESULTS: Mated females have high P:C intake relative to unmated females and mated, sterile females. Fertile females mated to wildtype males and to males lacking sex peptide have high P:C intake, but sterile females have similar, low P:C intake when unmated and when mated to males lacking sex peptide. CONCLUSIONS: The metabolic demands of egg production and sex peptides are individually sufficient to drive elevated P:C intake in adult female Drosophila. Reproductive state can thus modulate how animals consume macronutrients, which in turn can impact their health and aging.