Poor Prognosis of Colorectal Cancer in Patients Over 80 Years Old Is Associated With Down-Regulation of Tumor Suppressor Genes
Poor Prognosis of Colorectal Cancer in Patients Over 80 Years Old Is Associated With Down-Regulation of Tumor Suppressor Genes
复制标题
80岁以上患者结直肠癌预后不良与抑癌基因下调有关
DOI：
10.1097/00004836-200307000-00013
复制
发表时间：
2003
影响因子：
2.9
通讯作者：
K. Hirokawa
中科院分区：
文献类型：
--
作者：
S. Nagaoka;J. Shiraishi;M. Utsuyama;S. Seki;T. Takemura;M. Kitagawa;M. Sawabe;K. Takubo;K. Hirokawa
目的，背景在过去的半个世纪，老年人口一直在增加，了解衰老如何影响癌症的发生和生物学行为是很重要的。研究我们调查了1354例接受结直肠癌切除术的结直肠癌患者的临床病理特征，并比较了极老年患者（80岁以上）和中老年患者（40岁至80岁以下）的结果。此外，我们还研究了肿瘤抑制基因和考克斯-2的表达，从62例年龄从45岁到87岁不等的结直肠癌患者的冷冻标本。结果极高龄患者中女性比例较高，近端发生率较高，浸润深度较深者发生率较高，淋巴结转移者发生率较高，生存率较中老年患者低，p27和p53 mRNA表达水平较中老年患者低。结论80岁以上大肠癌患者预后不良与某些抑癌基因mRNA表达下调有关。
Goals, Background The elderly population has been increasing during the last half a century and it would be important to know how aging influences the occurrence and biologic behavior of cancers. Study We investigated clinicopathologic characteristics of colorectal cancer in 1354 patients who underwent colorectal cancer resection and compared the results between extremely elderly patients (over 80 years old) and middle-aged/elderly patients (40 to less than 80 years old). Furthermore, we also examined expression of tumor suppressor genes and Cox-2 using frozen samples of colorectal cancer obtained from 62 patients ranging in age from 45 to 87 years. Results The results obtained in the extremely aged patients were: (1) higher ratio of women, (2) higher incidence at the proximal site, (3) higher incidence of cases with deeper invasion, (4) higher incidence of cases with lymph node metastasis (5) poorer survival rate as compared with middle-aged/elderly patients, and (6) lower mRNA expression levels of p27 and p53. Conclusions These findings taken together suggest that poor prognosis of colorectal cancer in patients over 80 years is associated with down-regulation of mRNA expression of some tumor suppressor genes.
影响因子：
10.5
作者：
POLYAK, K;KATO, JY;KOFF, A
通讯作者：
KOFF, A
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC
影响因子：
56.9
作者：
BAKER, SJ;MARKOWITZ, S;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B