Four-component acyloxy-trifluoromethylation of arylalkenes mediated by photoredox catalyst
Four-component acyloxy-trifluoromethylation of arylalkenes mediated by photoredox catalyst
复制标题
光氧化还原催化剂介导的芳基烯烃的四组分酰氧基三氟甲基化
DOI：
10.1039/c8ob02239a
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发表时间：
2019
影响因子：
3.2
通讯作者：
Yuanbin She
中科院分区：
文献类型：
--
作者：
Xiaocong Zhou;Guijie Li;Zongzhou Shao;Kun Fang;Hongjun Gao;Yuanqiang Li;Yuanbin She
在光氧化还原催化剂 Ru(bpy)3(PF6)2 的存在下，在温和的反应条件下，开发了由可见光诱导的芳基烯烃的四组分分子间三氟甲基化-酰氧基化。采用新型梅本试剂作为三氟甲基自由基源，该氧化还原中性反应对芳基烯烃表现出良好的官能团耐受性，产率高达 91%。根据对照、氘和 O18 标记实验研究了详细的反应过程，以支持 N,N-二甲基甲酰胺 (DMF)/H2O 作为酰氧基源。
A four-component intermolecular trifluoromethylation–acyloxylation of arylalkenes induced by visible light has been developed in the presence of the photoredox catalyst Ru(bpy)3(PF6)2 under mild reaction conditions. A new Umemoto's reagent was used as a trifluoromethyl radical source, and this redox neutral reaction demonstrated good functional group tolerance for aryl alkenes with high yields up to 91%. The detailed reaction process was investigated based on control, deuterium and O18-labeling experiments to support that N,N-dimethylformamide (DMF)/H2O acted as an acyloxyl source.