Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar Typhimurium
Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar Typhimurium
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DOI：
10.1128/jb.182.13.3874-3876.2000
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发表时间：
2000-07-01
影响因子：
3.2
通讯作者：
Soncini, FC
中科院分区：
文献类型：
--
作者：
Aguirre, A;Lejona, S;Soncini, FC
沙门氏菌PmrA-Pmr B系统控制多粘菌素B抗性所必需的基因的表达。四个位点先前被确定为调节子的一部分，并观察到PmrA与其中三个的启动子区域的相互作用。在这里，我们的特点是相互作用的PmrA与ugd的启动子区域，以前建议由PmrA间接调节。我们的研究结果表明，PmrA控制ugd的表达，通过与该基因的启动子区域中的特定序列相互作用。
The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of PmrA with the promoter region of three of them was observed. Here we characterized the interaction of PmrA with the promoter region of ugd, previously suggested to be regulated indirectly by PmrA. Our results indicate that PmrA controls the expression of ugd by interacting with a specific sequence in the promoter region of this gene.