Self-seeding in cancer.
Self-seeding in cancer.
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DOI：
10.1007/978-3-642-28160-0_2
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Norton, Larry
中科院分区：
文献类型：
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作者：
Comen, Elizabeth;Norton, Larry
尽管我们对转移性癌症的理解和治疗取得了重大进展，但几乎所有转移性癌症都是不可治愈的。在这篇综述中，我们使用乳腺癌作为模型来强调我们现有的转移性疾病治疗范式的局限性和不一致性。反过来，我们提出了一种新的转移理论，称为“自我播种”。“在数学，实验和动物模型中得到充分验证的自我播种范例挑战了这样一种概念，即离开原发性肿瘤细胞的癌细胞在区域淋巴结和/或远处部位单向播种转移。相反，越来越多的证据表明，循环肿瘤细胞可以多向移动，不仅接种远处的部位，还接种它们的肿瘤起源。在这里，我们表明，自我播种模型可以回答许多内在的困惑，以了解癌症如何传播并最终杀死。事实上，将我们的研究和治疗工作重新定位在自我接种模型中可能会为根除转移性癌症提供新的可能性。
Despite significant progress in our understanding and treatment of metastatic cancer, nearly all metastatic cancers are incurable. In this Review, we use breast cancer as a model to highlight the limitations and inconsistencies of our existing treatment paradigms for metastatic disease. In turn, we offer a new theory of metastasis, termed "self-seeding. " The self-seeding paradigm, well validated in mathematical, experimental and animal models, challenges the notion that cancers cells that leave a primary tumor cell, unidirectionally seed metastases in regional lymph nodes and/or distant sites. In contrast, there is mounting evidence that circulating tumor cells can move multi-directionally, seeding not only distant sites but also their tumors of origin. Here, we show that the self-seeding model may answer many of the quandaries intrinsic to understanding how cancer spreads and ultimately kills. Indeed, redirecting our research and treatment efforts within the self-seeding model may offer new possibilities for eradicating metastatic cancer.