Regulation of RNA decay and cellular function by 3'-5' exoribonuclease DIS3L2.
Regulation of RNA decay and cellular function by 3'-5' exoribonuclease DIS3L2.
复制标题
DOI：
10.1080/15476286.2018.1564466
复制
发表时间：
2019
期刊：
影响因子：
4.1
通讯作者：
Li Zhaoyong
中科院分区：
文献类型：
--
作者：
Luan Siyu;Luo Junyun;Liu Hui;Li Zhaoyong
DIS3L2是一种具有3 ‘ -5 ’外核糖核酸酶活性的rna结合蛋白，其突变与帕尔曼综合征有关。它包含两个CSD结构域和一个S1结构域，它们都是rna结合结构域，以及一个负责外核糖核酸酶活性的RNB结构域。RNA底物的3′多尿苷可以作为DIS3L2的降解信号。由于DIS3L2主要定位于细胞质中，它可以识别、结合并介导细胞质尿苷化RNA的降解，包括前microRNA、成熟microRNA、mRNA和其他一些非编码RNA。因此，DIS3L2在细胞质RNA监视和衰变中起着重要作用。DIS3L2参与多种生物和生理过程，如细胞分裂、增殖、分化和凋亡。尽管如此，DIS3L2的功能，尤其是它与癌症的关系，在很大程度上仍然是未知的。我们在这里总结了DIS3L2降解的RNA底物及其核外溶活性，以及它所涉及的相应生物学功能。此外，我们讨论了DIS3L2是否可以独立于其3 ‘ -5 ’外核糖核酸酶活性发挥作用，以及在癌症进展过程中其潜在的肿瘤抑制或致癌作用。
DIS3L2, in which mutations have been linked to Perlman syndrome, is an RNA-binding protein with 3′-5′ exoribonuclease activity. It contains two CSD domains and one S1 domain, all of which are RNA-binding domains, and one RNB domain that is responsible for the exoribonuclease activity. The 3′ polyuridine of RNA substrates can serve as a degradation signal for DIS3L2. Because DIS3L2 is predominantly localized in the cytoplasm, it can recognize, bind, and mediate the degradation of cytoplasmic uridylated RNA, including pre-microRNA, mature microRNA, mRNA, and some other non-coding RNAs. Therefore, DIS3L2 plays an important role in cytoplasmic RNA surveillance and decay. DIS3L2 is involved in multiple biological and physiological processes such as cell division, proliferation, differentiation, and apoptosis. Nonetheless, the function of DIS3L2, especially its association with cancer, remains largely unknown. We summarize here the RNA substrates degraded by DIS3L2 with its exonucleolytic activity, together with the corresponding biological functions it is implicated in. Furthermore, we discuss whether DIS3L2 can function independently of its 3′-5′ exoribonuclease activity, as well as its potential tumor-suppressive or oncogenic roles during cancer progression.