Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers
Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers
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DOI：
10.1002/smll.201303921
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发表时间：
2014-10-29
期刊：
影响因子：
13.3
通讯作者：
Yang, Yi Yan
中科院分区：
文献类型：
--
作者：
Liu, Shao Qiong;Venkataraman, Shrinivas;Yang, Yi Yan
描述了基于刚性对苯二甲酰胺-双脲核、侧翼为咪唑鎓部分的新型阳离子分子。在水介质中，这些化合物自组装成具有不同形态的超分子纳米结构。该化合物具有最佳的亲水/疏水平衡，显示出有效的抗菌活性和对临床分离的 MRSA 的高选择性，且不会引起耐药性。这些自组装的阳离子抗菌纳米结构显示出预防和治疗多重耐药感染的希望。
Novel cationic molecules based on rigid terephthalamide-bisurea cores flanked by imidazolium moieties are described. In aqueous media, these compounds self-assemble into supramolecular nanostructures with distinct morphologies. The compound with optimal hydrophilic/hydrophobic balance displays potent antimicrobial activity and high selectivity towards clinically-isolated MRSA without inducing drug-resistance. These self-assembled cationic antimicrobial nanostructures show promise for the prevention and treatment of multidrug-resistant infections.