Coronal suturectomy does not cause acute postoperative displacement in the cranial bases of craniosynostotic rabbits.
Coronal suturectomy does not cause acute postoperative displacement in the cranial bases of craniosynostotic rabbits.
复制标题
冠状缝切除术不会引起颅缝早闭兔颅底术后急性移位。
DOI：
10.1097/00001665-200203000-00002
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Mooney,MarkP
中科院分区：
文献类型：
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作者：
Putz,DavidA;Weinberg,SethM;Smith,TimothyD;Burrows,AnneM;Cooper,GregoryM;Losken,HWolfgang;Siegel,MichaelI;Mooney,MarkP
每1，000，000名婴儿中约有300至500名婴儿的颅缝过早融合（颅缝早闭）。颅缝早闭可导致颅内压升高和颅面畸形，这通常需要广泛且昂贵的颅面手术。因为脑颅和基底颅在发育上是相互关联的，所以了解它们之间的相互影响对于手术计划是很重要的。虽然手术已被发现对颅缝早闭的人类和兔子的颅底有长期的影响，但这些影响背后的生物学机制仍然不确定。一些研究人员认为，手术松解骨缝改变了长期的生长模式，导致接受手术的颅缝早闭患者与未接受手术的患者之间的颅底差异。此外，一些研究者提出，急性和手术相关的移位颅底元素可能有助于观察到的差异。目前的研究探讨急性术后的变化，在四个长度，三个角度，和颅底标志之间的三个三角形在一个样本的7只新西兰白色兔与家族性非综合征性颅缝早闭。结果表明，缝切除术对颅底的急性长度、角度或形状差异无统计学意义（P< 0.05）。因此，之前在接受手术的家兔和未接受手术的家兔之间发现的长期颅底差异可能不是由手术导致的骨骼元件急性移位引起的。这些发现表明，术后颅底变化可能更多地与慢性生长模式改变有关，而不是与颅内压或硬脑膜张力的急性改变有关。
Approximately 300 to 500 infants per 1,000,000 have prematurely fused cranial sutures (craniosynostosis). Craniosynostosis can result in increased intracranial pressure and craniofacial deformities, which often require extensive and costly craniofacial surgery. Because the neurocranium and basicranium are developmentally interrelated, understanding their influence on one another is important for surgical planning. Although surgery has been found to have long-term effects on the cranial bases of craniosynostotic human beings and rabbits, the biological mechanisms behind these effects remain uncertain. Some researchers have suggested that the surgical release of synostosed sutures alters long-term growth patterns, resulting in cranial base differences between craniosynostotic individuals who undergo surgery and those who do not. Additionally, some investigators have proposed that an acute and surgically related displacement of basicranial elements may contribute to the observed differences. The current study examines acute postoperative changes in four lengths, three angles, and three triangles between cranial base landmarks in a sample of seven New Zealand white rabbits with familial nonsyndromic craniosynostosis. Results indicate that suturectomy caused no statistically significant (P< 0.05) acute length, angular, or shape differences in the cranial base. Thus, previous long-term cranial base differences found between rabbits that were operated on and those that were not were probably not caused by an acute displacement of skeletal elements as a result of surgery. These findings suggest that postoperative cranial base changes may be related more to chronically altered growth patterns than to acutely altered changes in intracranial pressure or dural tension.