Hemocompatibility evaluation with experimental and computational fluid dynamic analyses for a monopivot circulatory assist pump.
Hemocompatibility evaluation with experimental and computational fluid dynamic analyses for a monopivot circulatory assist pump.
复制标题
通过实验和计算流体动力学分析对单枢点循环辅助泵进行血液相容性评估。
DOI：
10.1111/j.1525-1594.2009.00730.x
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发表时间：
2009
影响因子：
2.4
通讯作者：
T. Tsutsui
中科院分区：
文献类型：
--
作者：
M. Nishida;O. Maruyama;R. Kosaka;T. Yamane;H. Kogure;H. Kawamura;Yoshihiro Yamamoto;K. Kuwana;Y. Sankai;T. Tsutsui
通过计算流体动力学 (CFD) 分析和粒子跟踪测速测量来评估新开发的单枢点循环辅助泵的血液相容性。将结果与溶血试验和体外抗血栓试验的结果进行比较，以防止泵内溶血和血栓形成。 CFD分析和粒子跟踪测速的结果具有很好的一致性。 CFD分析的流动分布表明，叶轮的径向射流足够弱，因此蜗壳壁上的壁面剪应力低于300 Pa。它与溶血测试结果一致，表明溶血水平低于市售泵的溶血水平。然而，流量分布也表明，容易停滞的枢轴不仅被通过叶轮后间隙的二次流冲走，而且还被二次叶片产生的涡流冲走。这与体外抗血栓试验结果相符，表明只有重新设计次级叶片的几何形状才能消除血栓形成。
The hemocompatibility of a newly developed monopivot circulatory assist pump was evaluated by the computational fluid dynamic (CFD) analyses with the particle tracking velocimetry measurement. Results were compared with those of the hemolysis test and in vitro antithrombogenic test to prevent hemolysis and thrombus formation inside the pump. The results of the CFD analysis and the particle tracking velocimetry had a good agreement with each other. The flow distributions by the CFD analysis indicated that the radial jet out of the impeller was adequately weak so that the wall shear stress was lower than 300 Pa on the volute casing wall. It corresponded with the hemolysis tests results, indicating that the hemolysis level was lower than that of the commercially available pump. However, the flow distributions also indicated that the pivot that was easy to stagnate was washed out, not only by the secondary flow through the back gap of the impeller, but also by the vortices generated by the secondary vanes. It corresponded with the in vitro antithrombogenic test results, indicating that thrombus formation could be removed only by redesigning the geometry of the secondary vanes.