Monitoring intracellular, interstitial, and intravascular volume changes during fluid management procedures.
Monitoring intracellular, interstitial, and intravascular volume changes during fluid management procedures.
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DOI：
10.1007/s11517-013-1064-3
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发表时间：
2013-10
影响因子：
3.2
通讯作者：
Velasquez, Manuel T.
中科院分区：
文献类型：
--
作者：
Montgomery, Leslie D.;Gerth, Wayne A.;Montgomery, Richard W.;Lew, Susie Q.;Klein, Michael M.;Stewart, Julian M.;Velasquez, Manuel T.
本报告中描述的生物阻抗谱（BIS）分析算法允许在各种液体管理程序期间无创测量血管内、间质和细胞内容积变化。本研究旨在测试临床使用可行性，并证明BIS算法在计算接受液体管理治疗的人类受试者的房室容积变化方面的有效性。使用20例终末期肾病（ESRD）患者记录的体积变化进行验证。验证程序涉及从BIS数据生成的液体再分布时间曲线数学推导事后红细胞压积曲线。然后将这些推导出的红细胞压积曲线与在60次常规血液透析（HD）期间通过CritLine®监测仪同时测量的系列红细胞压积值进行比较。回归和Bland Altman分析证实，BIS算法可用于可靠地推导房室液体容量的连续和真实的时间变化率。回归结果表明，透析期间不同时间的两种红细胞压积测量值之间的R2 > 0.99。不同时间的回归方程的斜率几乎相同，证明BIS和CritLine®血细胞比容之间几乎一一对应。Bland Altman分析表明，BIS算法可与CritLine®监护仪互换使用，以测量红细胞压积。本研究首次证明，当与这种新算法结合使用时，BIS可以在液体管理程序期间提供房室血管内、间质和细胞内液体体积变化的实时连续测量。
The bioimpedance spectroscopic (BIS) analytical algorithm described in this report allows for the non-invasive measurement of intravascular, interstitial, and intracellular volume changes during various fluid management procedures. The purpose of this study was to test clinical use feasibility and to demonstrate the validity of the BIS algorithm in computing compartmental volume shifts in human subjects undergoing fluid management treatment. Validation was performed using volume changes recorded from 20 end stage renal disease (ESRD) patients. The validation procedure involved mathematically deriving post hoc hematocrit profiles from the BIS data-generated fluid redistribution time profiles. These derived hematocrit profiles were then compared to serial hematocrit values measured simultaneously by a CritLine® monitor during 60 routine hemodialysis (HD) sessions. Regression and Bland Altman analyses confirm that the BIS algorithm can be used to reliably derive the continuous and real time rates of change of the compartmental fluid volumes. Regression results yielded a R2 > 0.99 between the two measures of hematocrit at different times during dialysis. The slopes of the regression equations at the different times were nearly identical, demonstrating an almost one to one correspondence between the BIS and CritLine® hematocrits. Bland Altman analyses show that the BIS algorithm can be used interchangeably with the CritLine® monitor for the measurement of hematocrit. The present study demonstrates for the first time that BIS can provide real-time continuous measurements of compartmental intravascular, interstitial and intracellular fluid volume changes during fluid management procedures when used in conjunction with this new algorithm.
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DOI：
10.1085/jgp.9.2.153
发表时间：
1925-11-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
Fricke H;Morse S
通讯作者：
Morse S
影响因子：
4.4
作者：
Cole, KS;Cole, RH
通讯作者：
Cole, RH
影响因子：
--
作者：
Fricke, H
通讯作者：
Fricke, H
影响因子：
3.2
作者：
FRICKE, H
通讯作者：
FRICKE, H
影响因子：
2.7
作者：
DURBIN, J;WATSON, GS
通讯作者：
WATSON, GS