Sleep deprivation and a non-24-h working schedule lead to extensive alterations in physiology and behavior
Sleep deprivation and a non-24-h working schedule lead to extensive alterations in physiology and behavior
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睡眠不足和非 24 小时工作安排会导致生理和行为的广泛改变
DOI：
10.1096/fj.201802727r
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发表时间：
2019-06-01
期刊：
影响因子：
4.8
通讯作者：
Guo, Jinhu
中科院分区：
文献类型：
--
作者：
Ma, Huan;Li, Yunzhen;Guo, Jinhu
地球上的大多数生物在他们的生理和行为上都有昼夜节律，这使得他们能够在24小时内与自行车环境产生共鸣。然而，在人类社会中，大量的工作需要非24小时的工作和休息或轮班时间表，这或多或少会导致昼夜节律的失调和紊乱。在这项工作中，我们进行了为期10天的睡眠剥夺(SD)和非24小时工作和休息(8h和4h)实验，并测量了一系列生理和认知参数的变化。结果表明，虽然受试者可以在日程安排中睡觉，但他们的困倦程度显著增加。动作图数据表明，12小时的时间表可能会导致慢性SD。随着Karolinska嗜睡量表问卷显示的困倦程度的增加，神经行为精神运动警觉测试数据显示，与控制期相比，受试者的反应时显著延迟。SD周期和非24小时周期的清晨唾液胰岛素水平均有显著变化。唾液生化指标也发生改变，包括天冬氨酸转氨酶和K+。基于16S rRNA的唾液微生物区系分析显示，细菌组成和浓度发生了不同的变化。综上所述，这些数据表明，不正常的作息时间表可能会对昼夜节律、新陈代谢和认知产生全面的干扰。-Ma，H.，Li，Y.，梁，H.，Chen，S.，潘，S.，Chang，L.，Li，S.，Zhang，Y.，Liu，X.，Xu，Y.，Shao，Y.，Yang，Y.，Guo，J.睡眠不足和非24小时工作时间表导致生理和行为的广泛变化。
Most organisms on Earth possess circadian rhythms in their physiology and behaviors that allow them to resonate with the cycling environment over a 24-h period. However, in human society, a substantial quantity of jobs requires non-24-h working and rest or shift schedules, which causes more or less misalignment in circadian rhythms and disorders as a consequence. In this work, we conducted a sleep deprivation (SD) and non-24-h working and rest schedule (8 h on and 4 h off) experiment over 10 d in total and measured the changes in a series of physiologic and cognitive parameters. The results show that although the subjects could sleep during the schedule, their sleepiness increased significantly. Actigraphy data suggest that a 12-h schedule might result in chronic SD. Along with the increased sleepiness revealed by the Karolinska Sleepiness Scale questionnaire, the neurobehavioral psychomotor vigilance test data reveal that, compared with the control period, the reaction time of the subjects was significantly delayed. The saliva insulin levels were significantly changed in the morning in SD and non-24-h cycles. Salivary biochemical parameters were also altered, including aspartate aminotransferase and K+. 16S rRNA-based analysis of the salivary microbiota showed differentially changed patterns in bacteria composition and concentration. Together, these data demonstrate that an abnormal working and rest schedule might produce comprehensive interference with circadian rhythms, metabolism, and cognition.-Ma, H., Li, Y., Liang, H., Chen, S., Pan, S., Chang, L., Li, S., Zhang, Y., Liu, X., Xu, Y., Shao, Y., Yang, Y., Guo, J. Sleep deprivation and a non-24-h working schedule lead to extensive alterations in physiology and behavior.