Weight Control Program and Gestational Weight Gain in Disadvantaged Women with Overweight or Obesity: A Randomized Clinical Trial.

Weight Control Program and Gestational Weight Gain in Disadvantaged Women with Overweight or Obesity: A Randomized Clinical Trial.
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DOI:
10.1002/oby.22070
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发表时间:
2018-03
期刊:
Obesity (Silver Spring, Md.)
影响因子:
--
通讯作者:
Klein S
Klein S
中科院分区:
其他
文献类型:
--
作者:
Cahill AG;Haire-Joshu D;Cade WT;Stein RI;Woolfolk CL;Moley K;Mathur A;Schechtman K;Klein S

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评估通过家长作为教师(PAT)提供的以家庭为基础的生活方式干预对减少过度GWG的效果。这是一项单盲、随机对照试验,作为LIFE-Moms联盟的一部分,于2012年10月至2016年3月在一家大学三级医疗机构进行。有267名SED非裔美国妇女在怀孕前超重或肥胖(BMI 25.0-45.0 kg/m2)。参与者被随机分配到单独使用标准PAT(n=134)或PAT+嵌入标准PAT程序中的生活方式干预程序(PAT+,n=133)。两种干预措施都是在怀孕期间每两周进行10次家访。主要结果是GWG超过IOM指南的女性百分比,次要结果包括每周和总GWG。在意向治疗分析中,与标准PAT组相比,PAT+组妊娠期间每周体重增加(0.4 kg v. 0.5 kg/周,P=0.04)和总体重增加(8.0 kg v. 9.6 kg,P=0.02)较少。PAT+组中总GWG过多的受试者较少(36.1% vs 45.9%),但组间差异无统计学意义(P=0.11)。PAT+减少每周和总GWG在SED非洲裔美国妇女超重或肥胖在怀孕开始。
To evaluate the efficacy of a home-based lifestyle intervention delivered through Parents as Teachers (PAT) to reduce excessive GWG. This was a single-blinded, randomized controlled trial conducted as part of the LIFE-Moms consortium at a single university-based tertiary care institution, from October 2012 to March 2016. There were 267 SED African-American women with overweight or obesity (BMI 25.0–45.0 kg/m2) before pregnancy. Participants were randomized to therapy with standard PAT alone (n=134) or PAT+ a lifestyle intervention program embedded within the standard PAT program (PAT+, n=133). Both interventions were delivered in 10-biweekly home visits during pregnancy. The primary outcome was percentage of women whose GWG exceeded IOM guidelines, and secondary outcomes included both weekly and total GWG. Compared with the standard PAT group in the intent-to-treat analysis, the PAT+ group gained less weekly (0.4 kg v. 0.5 kg per week, P=0.04) and total (8.0 kg v. 9.6 kg, P=0.02) weight during gestation. Fewer participants in the PAT+ group had excessive total GWG (36.1% vs 45.9%), but the difference between groups was not statistically significant (P=0.11). PAT+ reduced weekly and total GWG in SED African-American women with overweight or obesity at the start of pregnancy.
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