A neurotoxin that specifically targets Anopheles mosquitoes
A neurotoxin that specifically targets Anopheles mosquitoes
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DOI：
10.1038/s41467-019-10732-w
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发表时间：
2019-06-28
影响因子：
16.6
通讯作者：
Gill, Sarjeet S.
中科院分区：
文献类型：
--
作者：
Contreras, Estefania;Masuyer, Geoffrey;Gill, Sarjeet S.
梭菌神经毒素，包括破伤风和肉毒杆菌神经毒素，通常靶向脊椎动物。我们在这里表明，这个家族的毒素有一个更广泛的宿主谱，通过识别PMP 1，梭菌样神经毒素，选择性地针对按蚊。从两大洲按蚊流行区采集的双酶副梭菌菌株中分离到PMP 1，表明其分布广泛。这种毒素可能是从一种祖先形式进化而来的，它以类似生物的神经系统为目标，使用一种破坏SNARE介导的胞吐作用的共同机制。它切割蚊子的突触融合蛋白，并采用独特的受体识别策略。我们的研究对梭菌神经毒素的进化研究产生了重要影响，并为使用双酶假单胞菌菌株和PMP 1作为创新、环保的方法通过按蚊控制来减少疟疾提供了基础。
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.