Chemical warfare - Nerve agent poisoning
Chemical warfare - Nerve agent poisoning
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DOI：
10.1016/s0749-0704(05)70374-2
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发表时间：
1997-10-01
影响因子：
4.3
通讯作者：
Sidell, FR
中科院分区：
文献类型：
--
作者：
Holstege, CP;Kirk, M;Sidell, FR
神经毒剂是有机磷酸抗胆碱酯酶，在过去十年中引起了媒体的极大关注。一般媒体本身对这些毒剂的经验有限，但日本最近的经验表明，重症监护人员可能面临大量平民因神经毒剂暴露而伤亡的情况。本文旨在对神经毒剂中毒的历史、化学性质、病理生理和治疗进行综述。文章讨论了四种主要的神经毒剂：塔崩、沙林、梭曼和VX。
Nerve agents are organophosphate anticholinesterases that have commanded a great deal of media attention in the past decade. The general media community itself has limited experience with these agents, but the recent experience in Japan points out that intensivists may be confronted with large numbers of civilian casualties from nerve agent exposure. The purpose of this article is to provide a general review of the history, chemical properties, pathophysiology, and treatment of nerve agent poisoning. The article discusses the four main nerve agents: tabun, sarin, soman, and VX.