Fear-potentiated startle conditioning to explicit and contextual cues in gulf war veterans with posttraumatic stress disorder
Fear-potentiated startle conditioning to explicit and contextual cues in gulf war veterans with posttraumatic stress disorder
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DOI：
10.1037/0021-843x.108.1.134
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发表时间：
1999-02-01
影响因子：
4.6
通讯作者：
Morgan, CA
中科院分区：
文献类型：
--
作者：
Grillon, C;Morgan, CA
通过使用惊吓反射方法，研究了患有或不患有创伤后应激障碍（PTSD）的海湾战争退伍军人对明确和情境线索的厌恶条件反射。退伍军人参加了一项差别厌恶调节实验，该实验包括 2 次间隔 4 或 5 天的实验。每个阶段包括两个惊吓习惯期、预适应阶段、适应阶段和后适应消退测试。与非 PTSD 组相比，PTSD 组在第 1 节中表现出在有条件刺激（有或没有无条件刺激）的情况下缺乏差异性惊吓反应，而在第 2 节中基线惊吓反应有所增加。在第 2 节中的再调节后，PTSD 组也表现出正常的差异性条件反射。这些数据表明，患有 PTSD 的个体倾向于将恐惧泛化到刺激中，并且对压力敏感。
Aversive conditioning to explicit and contextual cues was examined in Gulf War veterans with and without posttraumatic stress disorder (PTSD) by use of the startle reflex methodology. Veterans participated in a differential aversive conditioning experiment consisting of 2 sessions separated by 4 or 5 days. Each session comprised two startle habituation periods, a preconditioning phase, a conditioning phase, and a postconditioning extinction test. In contrast to the non-PTSD group, the PTSD group showed a lack of differential startle response in the presence of a conditioned stimulus with or without an unconditioned stimulus in Session 1 and an increase in the baseline startle response during Session 2. The PTSD group also exhibited normal differential conditioning following reconditioning in Session 2. These data suggest that individuals with PTSD tend to generalize fear across stimuli and are sensitized by stress.