AGE-RELATED MORPHOLOGICAL-CHANGES IN LID MARGIN AND MEIBOMIAN GLAND ANATOMY
AGE-RELATED MORPHOLOGICAL-CHANGES IN LID MARGIN AND MEIBOMIAN GLAND ANATOMY
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DOI：
10.1097/00003226-199207000-00012
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发表时间：
1992-07-01
期刊：
影响因子：
2.8
通讯作者：
BRON, AJ
中科院分区：
文献类型：
--
作者：
HYKIN, PG;BRON, AJ
睑板腺功能障碍（MGD）是负责反复刺激症状。试图表征MGD主要集中在睑板腺分泌物中的微生物和脂质异常。很少有报道描述这种疾病的组织学异常，更少的形态学变化。本文遵循先前的研究，建立了MGD的分类。这是基于睑板腺和眼睑边缘的形态学变化。使用这种分类，我们研究了80名受试者的年龄相关变化，年龄在5至87岁之间，没有眼部疾病。儿童期后睑缘增厚。眼睑边缘血管和皮肤角化过度随着年龄的增长而增加，而随着年龄的增长，在下眼睑和鳞状睑缘炎和后眼睑边缘圆化的毛细血管扩张增加50岁后，在上眼睑更常见。多排睑板腺口出现在上睑多于下睑，口狭窄和噘起随年龄增长而增加。粘膜皮肤功能、腺管或腺泡的形状或形式没有发现与年龄相关的变化。老年人睑板腺分泌物不易表达。我们试图确定健康儿童和成人眼睑形态的正常范围，我们认为这对随后定义眼睑疾病，特别是后睑缘炎很重要。
Meibomian gland dysfunction (MGD) is responsible for recurrent irritative symptoms. Attempts to characterize MGD have largely concentrated on microbial and lipid abnormalities in meibomian gland secretions. Few reports describe histological abnormalities in this disease, and fewer still morphological changes. This article follows a previous study that established a classification for MGD. This was based on morphological changes in the meibomian gland and lid margin. Using this classification, we studied the age-related changes in 80 subjects, between 5 and 87 years of age without ocular disease. The lid margin became thicker after childhood. Lid margin vascularity and cutaneous hyperkeratinization increased with age in both lids, whereas, telangiectasia increased with age in the lower lid and squamous blepharitis and posterior lid margin rounding were more common after 50 years of age in the upper lid. Multiple rows of meibomian gland orifices occurred more frequently in the upper than lower lid, and orifice narrowing and pouting increased with age. No age-related changes in the shape or form of the mucocutaneous function, gland ducts, or acini were found. Meibomian gland secretions were less easily expressed in the elderly. We have attempted to define a normal range of lid morphology in healthy children and adults that we believe to be important for the subsequent definition of lid disease, and in particular, posterior blepharitis.