A selective 'Off-On' fluorescent sensor for Zn(2+) based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn(2+).

A selective 'Off-On' fluorescent sensor for Zn(2+) based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn(2+).
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DOI:
10.1016/j.bmcl.2009.11.028
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发表时间:
2010
影响因子:
2.7
通讯作者:
Ying Zhou;Ha na Kim;Juyoung Yoon
Ying Zhou;Ha na Kim;Juyoung Yoon
中科院分区:
医学4区
文献类型:
--
作者:
Ying Zhou;Ha na Kim;Juyoung Yoon

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合成了一种简单有效的基于腙-芘的荧光传感器。该探针显示出对Zn 2+的高度选择性荧光增强,并且成功地证明了该探针用于检测胰腺β细胞中存在的固有Zn 2+离子的应用。
A simple and effective fluorescent sensor based on hydrazone–pyrene has been synthesized. This probe displays a highly selective fluorescent enhancement with Zn2+, and application of this probe to detect the intrinsic Zn2+ions present in pancreatic β-cells was successfully demonstrated.