Hypoxic Stress Upregulates the Expression of <b><i>Slc38a1</i></b> in Brown Adipocytes via Hypoxia-Inducible Factor-1α
Hypoxic Stress Upregulates the Expression of <b><i>Slc38a1</i></b> in Brown Adipocytes via Hypoxia-Inducible Factor-1α
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缺氧应激通过缺氧诱导因子-1α上调棕色脂肪细胞<b><i>Slc38a1</i></b>的表达
DOI：
10.1159/000480405
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发表时间：
2017
期刊：
影响因子：
3.1
通讯作者：
Hinoi Eiichi
中科院分区：
文献类型：
--
作者：
Horie Tetsuhiro;Fukasawa Kazuya;Iezaki Takashi;Park Gyujin;Onishi Yuki;Ozaki Kakeru;Kanayama Takashi;Hiraiwa Manami;Kitaguchi Yuka;Kaneda Katsuyuki;Hinoi Eiichi
棕色脂肪组织（BAT）中氨基酸的可利用性在不同条件下会发生变化，但在生理和病理条件下BAT中氨基酸转运蛋白的表达及其关键作用尚不清楚。本研究全面调查了氨基酸转运蛋白是否受体内BAT中致肥胖条件的调节。此外，我们研究了各种应激物在体外棕色脂肪细胞中调节氨基酸转运蛋白表达的机制。溶质载体家族38成员1（Slc 38 a1;编码钠偶联中性氨基酸转运蛋白1的基因）的表达在体内遗传性和获得性肥胖小鼠的BAT中优先上调。此外，低氧应激通过低氧诱导因子1α（hypoxia-inducible factor-1α，HIF-1α）诱导棕色脂肪细胞Slc 38 a1的表达。这些结果表明，Slc 38 a1是BAT中的肥胖相关基因和棕色脂肪细胞中的缺氧反应基因。
The availability of amino acid in the brown adipose tissue (BAT) has been shown to be altered under various conditions; however, little is known about the possible expression and pivotal role of amino acid transporters in BAT under physiological and pathological conditions. The present study comprehensively investigated whether amino acid transporters are regulated by obesogenic conditions in BAT in vivo. Moreover, we investigated the mechanism underlying the regulation of the expression of amino acid transporters by various stressors in brown adipocytes in vitro. The expression of solute carrier family 38 member 1 (Slc38a1; gene encoding sodium-coupled neutral amino acid transporter 1) was preferentially upregulated in the BAT of both genetic and acquired obesity mice in vivo. Moreover, the expression of Slc38a1 was induced by hypoxic stress through hypoxia-inducible factor-1α, which is a master transcription factor of the adaptive response to hypoxic stress, in brown adipocytes in vitro. These results indicate that Slc38a1 is an obesity-associated gene in BAT and a hypoxia-responsive gene in brown adipocytes.
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DOI：
10.1073/pnas.89.12.5606
发表时间：
1992-06-15
影响因子：
11.1
作者：
BERTRAN, J;MAGAGNIN, S;MURER, H
通讯作者：
MURER, H
影响因子：
5.5
作者：
Netzer N;Gatterer H;Faulhaber M;Burtscher M;Pramsohler S;Pesta D
通讯作者：
Pesta D
影响因子：
64.8
作者：
Tseng, Yu-Hua;Kokkotou, Efi;Schulz, Tim J.;Huang, Tian Lian;Winnay, Jonathon N.;Taniguchi, Cullen M.;Tran, Thien T.;Suzuki, Ryo;Espinoza, Daniel O.;Yamamoto, Yuji;Ahrens, Molly J.;Dudley, Andrew T.;Norris, Andrew W.;Kulkarni, Rohit N.;Kahn, C. Ronald
通讯作者：
Kahn, C. Ronald
DOI：
10.1073/pnas.140152797
发表时间：
2000-07-05
影响因子：
11.1
作者：
Reimer, RJ;Chaudhry, FA;Edwards, RH
通讯作者：
Edwards, RH
影响因子：
6.2
作者：
Hinoi, Eiichi;Ochi, Hiroki;Yoneda, Yukio
通讯作者：
Yoneda, Yukio