Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model
Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model
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硼中子俘获治疗对人盆腔结直肠癌小鼠模型的抑瘤作用
DOI：
10.1016/j.biopha.2022.113632
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发表时间：
2022-09-02
影响因子：
7.5
通讯作者：
Lee, Sang-Woong
中科院分区：
文献类型：
--
作者：
Arima, Jun;Taniguchi, Kohei;Lee, Sang-Woong
结直肠癌（CRC）在根治性切除后可能会出现局部复发，因此可能需要进行额外的手术切除；然而，这对患者来说是一个重大负担，因为额外的手术切除可能需要切除其他器官，如膀胱、前列腺、子宫或骶骨。因此，需要替代的治疗策略。我们专注于硼中子捕获疗法（BNCT）作为一种治疗方式，可以选择性地靶向肿瘤细胞，而不会对正常组织造成过度损伤。 BNCT 对盆腔结直肠癌的有用性仍不清楚。本研究在先前建立的 CRC 盆腔复发小鼠模型中调查了苯苯丙氨酸 (BPA) 介导的 BNCT 的抗癌作用。在体外和体内均观察到 CRC 中 BPA 的摄取，并且浓度足以进行 BNCT。我们的研究结果首次表明，BPA 介导的 BNCT 可以延长患有盆腔肿瘤的实验小鼠的生存期；此外，它没有对接受治疗的动物造成任何明显的严重副作用。总之，BPA 介导的 BNCT 可能有助于治疗盆腔结直肠癌的局部复发。
Local recurrence of colorectal cancer (CRC) can occur in patients after curative resection, and additional surgical resection may therefore be required; however, this is a significant burden for patients, because additional surgical resection may necessitate the resection of other organs such as the bladder, prostate, uterus, or sacral bone. Therefore, there is a need for alternative therapeutic strategies. We focused on boron neutron capture therapy (BNCT) as a treatment modality that can selectively target tumor cells without excessive damage to normal tissues. The usefulness of BNCT to pelvic CRC remains unknown. This study investigated the anti-cancer effect of bomnophenylalanine (BPA)-mediated BNCT in a previously established mouse model of pelvic recurrence of CRC. Uptake of BPA in CRC was observed both in vitro and in vivo, and the concentrations were sufficient for BNCT. Our results are the first to show that BPA-mediated BNCT prolonged the survival of experimental mice with pelvic tumors; moreover, it did not cause any obvious severe side effects in the treated animals. In conclusion, BPA-mediated BNCT could contribute to treating local recurrence of pelvic CRC.