Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut.
Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut.
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DOI：
10.1080/10409238.2016.1243654
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发表时间：
2017-02
影响因子：
6.5
通讯作者：
Nolan EM
中科院分区：
文献类型：
--
作者：
Chairatana P;Nolan EM
在肠道中，粘膜免疫系统在维持宿主与微生物之间的动态平衡以及保护宿主免受病原性入侵方面发挥着重要作用。上皮细胞产生并释放各种生物分子进入粘膜和管腔，有助于免疫。在这篇综述中，我们关注这些显著的宿主防御因子的一个子集-肠道α-防御素，选择凝集素，粘蛋白和分泌型免疫球蛋白A -它们具有结合微生物的能力，从而有助于人类肠道的屏障功能。我们提供了一个概述的肠上皮，描述专门的分泌细胞命名为潘氏细胞，并总结了我们目前的理解，这些选择微生物结合生物分子的生物物理和功能特性。我们打算这个汇编，以补充以前的审查肠道宿主防御因子，强调在该领域的最新进展，并激励调查，进一步阐明分子机制以及这些分子和微生物之间的相互作用。
In the intestine, the mucosal immune system plays essential roles in maintaining homeostasis between the host and microorganisms, and protecting the host from pathogenic invaders. Epithelial cells produce and release a variety of biomolecules into the mucosa and lumen that contribute to immunity. In this review, we focus on a subset of these remarkable host-defense factors – enteric α-defensins, select lectins, mucins, and secretory immunoglobulin A – that have the capacity to bind microbes and thereby contribute to barrier function in the human gut. We provide an overview of the intestinal epithelium, describe specialized secretory cells named Paneth cells, and summarize our current understanding of the biophysical and functional properties of these select microbe-binding biomolecules. We intend for this compilation to complement prior reviews on intestinal host-defense factors, highlight recent advances in the field, and motivate investigations that further illuminate molecular mechanisms as well as the interplay between these molecules and microbes.