Transdermal delivery of insulin by ultrasonic vibration
Transdermal delivery of insulin by ultrasonic vibration
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DOI：
10.1111/j.2042-7158.1991.tb06681.x
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发表时间：
1991-04
影响因子：
3.3
通讯作者：
K. Tachibana;S. Tachibana
中科院分区：
文献类型：
--
作者：
K. Tachibana;S. Tachibana
超声振动已被用于将胰岛素通过禁食过夜的无毛小鼠皮肤，并部分浸入胰岛素水溶液（20单位mL−1）。皮肤表面在超声能量范围（3000 - 5000pa和5000 - 8000pa）下以48khz暴露5min。测量胰岛素和超声振动前后的血糖浓度。低能量振动组的血糖在120分钟内迅速下降，达到对照值的34±11.9%，而高能量振动组的血糖在120分钟内下降了对照值的22.4±3.9%。该数值在实验期间（240 min）保持较低。那些单独暴露于胰岛素或超声波振动的人的血糖浓度没有明显变化。据推测，超声波振动可能会改变皮肤的渗透性，从而导致胰岛素的吸收。在两个能量范围中，血糖下降的幅度越大，这表明这个因素可以控制胰岛素的输送。
Abstract— Ultrasonic vibration has been used to deliver insulin through the skin of hairless mice fasted overnight and partially immersed in an aqueous solution of insulin (20 units mL−1). The skin surface was exposed to ultrasonic vibration in two ultrasonic energy ranges (3000–5000 Pa and 5000–8000 Pa) at 48 kHz for 5 min. Blood glucose concentration was measured before and after exposure to insulin and ultrasonic vibration. In the group subjected to the lower energy vibrations, blood glucose fell rapidly to reach 34 ± 11.9% of control values in 120 min, while when the animals were exposed to higher energy vibrations, the fall in blood glucose was 22.4 ± 3.9% of control values at 120 min. The values remained low for the length of the experiment (240 min). Those exposed to insulin alone or ultrasonic vibration alone revealed no significant change in blood glucose concentration. It is postulated that ultrasonic vibration may alter skin permeability resulting in the absorption of insulin. That the blood glucose decrease was greater at the higher of the two energy ranges, suggests this factor could control insulin delivery.