Peptide YY inhibits meal-stimulated pancreatic and gastric secretion.
Peptide YY inhibits meal-stimulated pancreatic and gastric secretion.
复制标题
肽 YY 抑制膳食刺激的胰腺和胃分泌。
DOI：
10.1152/ajpgi.1985.248.1.g118
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Taylor,IL
中科院分区：
文献类型：
--
作者：
Pappas,TN;Debas,HT;Goto,Y;Taylor,IL
肽YY最近从猪肠中分离出来，并显示出与胰腺多肽（胰腺外分泌的有效抑制剂）具有显著的结构同源性。我们研究了输注肽YY对四只患有胃和胰腺瘘的杂种狗的胃和胰腺分泌的影响。胃内滴注15%肝提取物膳食，并将生理盐水或三种剂量的肽YY（200、400和800 pmol X kg-1 X h-1）之一输注到外周静脉中。所有三种剂量的肽YY均显著抑制膳食刺激的胰液和碳酸氢盐分泌，最低剂量分别抑制分泌44.5 +/-3.5%和53.6 +/-8.5%。两个最高剂量均显著抑制胰腺蛋白分泌和胃酸分泌。200、400和800 pmol X kg-1 X h-1剂量的肽YY分别与外周血中201 +/- 24、357 +/- 50和971 +/- 139 pM的增量相关。这些值与86.3 +/- 8.5 pM的平均增量相比，在肉类餐后和403 +/- 63 pM的平均增量后，脑灌注油酸。目前的研究表明，肽YY抑制胃和胰腺分泌，并表明肽YY可能是回结肠粘膜中的胃和胰腺抑制剂，其通过用油酸灌注肠而释放。
Peptide YY was recently isolated from porcine intestine and shown to exhibit marked structural homology with pancreatic polypeptide, a potent inhibitor of pancreatic exocrine secretion. We have examined the effects of infused peptide YY on gastric and pancreatic secretion in four mongrel dogs with gastric and pancreatic fistulas. A 15% liver extract meal was instilled intragastrically, and normal saline or one of three doses of peptide YY (200, 400, and 800 pmol X kg-1 X h-1) was infused into a peripheral vein. All three doses of peptide YY significantly inhibited meal-stimulated pancreatic fluid and bicarbonate secretion, with the lowest dose inhibiting secretion by 44.5 +/- 3.5 and 53.6 +/- 8.5%, respectively. Pancreatic protein secretion and gastric acid secretion were significantly inhibited by the two highest doses. The 200, 400, and 800 pmol X kg-1 X h-1 doses of peptide YY were associated with increments in peripheral blood of 201 +/- 24, 357 +/- 50, and 971 +/- 139 pM, respectively. These values compared with mean increments of 86.3 +/- 8.5 pM after a meat meal and 403 +/- 63 pM after intestinally perfused oleic acid. The present studies demonstrate that peptide YY inhibits gastric and pancreatic secretion and suggest that peptide YY may be the gastric and pancreatic inhibitor in ileocolonic mucosa that is released by perfusion of the intestine with oleic acid.