Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy
Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy
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DOI：
10.1111/aos.14348
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发表时间：
2020-01-13
影响因子：
3.4
通讯作者：
Lund-Andersen, Henrik
中科院分区：
文献类型：
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作者：
Ba-Ali, Shakoor;Brondsted, Adam Elias;Lund-Andersen, Henrik
目的评价伴非增殖性糖尿病视网膜病变（NPDR）的1型糖尿病（T1DM）和2型糖尿病（T2DM）患者视杆/视锥细胞和黑视素的功能。方法对22例健康对照和4组糖尿病患者进行瞳孔测量，其中T2DM无NPDR组12例，中度NPDR组12例，T2DM无NPDR组16例，中度NPDR组12例。以15对数量子/厘米(2)/秒的速度进行20秒的红光（λ = 633 nm）和蓝光（λ = 463 nm）单目刺激。主要终点是黑视素介导的照射后瞳孔光反应（PIPRLate）对蓝光的后期再扩张阶段。次要结果是混合杆/锥和黑视素反应，即最大瞳孔收缩和PIPR的早期再扩张期（PIPREarly）。结果健康对照组与4组糖尿病患者在蓝光和红光刺激下PIPR的后期再扩张期（PIPRLate）无显著差异（p < 0.05）。T1DM患者以及合并NPDR的T2DM患者在蓝光刺激下瞳孔最大收缩量显著降低(p
Objective We assessed the function of rod/cones and melanopsin in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) with and without non-proliferative diabetic retinopathy (NPDR). Methods We performed pupillometry on 22 healthy controls and four diabetic groups: 12 T1DM patients without NPDR and 12 with moderate NPDR, and 16 T2DM patients without NPDR and 12 with moderate NPDR. Monocular stimulations of 20 seconds with red (lambda = 633 nm) and blue light (lambda = 463 nm) at 15 log quanta/cm(2)/second were performed. The primary outcome was the melanopsin-mediated late redilation phase of postillumination pupillary light response (PIPRLate) to blue light. The secondary outcomes were the mixed rod/cone and melanopsin responses, that is maximal pupil constriction and the early redilation phase of PIPR (PIPREarly). Results Late redilation phase of PIPR (PIPRLate) to blue and red light stimuli was not significantly different between healthy control and the four diabetic groups (n.s.). The maximal pupil contractions to blue light stimulus were significantly reduced in T1DM patients as well as in T2DM patients with NPDR (p