Focus on molecules: galectin-3.
Focus on molecules: galectin-3.
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DOI：
10.1016/j.exer.2010.11.009
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发表时间：
2011-01
影响因子：
3.4
通讯作者：
Panjwani, Noorjahan
中科院分区：
文献类型：
--
作者：
Argueeso, Pablo;Panjwani, Noorjahan
关键词：
半乳糖凝集素是由两个标准定义的动物凝集素家族：对β半乳糖苷的亲和力和存在至少一个进化上保守的碳水化合物结合结构域（Dumic，J. 2006年）。它们存在于所有检查的后生动物中，从海绵和真菌到无脊椎动物和脊椎动物。迄今为止，在哺乳动物中已经鉴定了多达15种半乳糖凝集素，它们广泛分布于不同类型的细胞和组织中。LGALS 3由6个外显子和5个内含子组成，总共跨越1017个碱基（图1A）。外显子IV至VI编码含有碳水化合物识别结构域（CRD）的C末端结构域。外显子III和外显子II的18 bp编码一个长而灵活的N-末端结构域，该结构域包含丝氨酸磷酸化位点和其他对蛋白质的非经典分泌重要的决定因素。由于与CRD相邻的N-末端结构域的存在，半乳糖凝集素-3被分类为嵌合型半乳糖凝集素。
Galectins are a family of animal lectins defined by two criteria: affinity towards βgalactosides and the presence of at least one evolutionary conserved carbohydrate-binding domain (Dumic, J. et al., 2006). They are found in all metazoans examined, from sponges and fungi, to both invertebrates and vertebrates. As many as 15 galectins have been identified to-date in mammals, and they are widely distributed among different types of cells and tissues.Human galectin-3 is a 35-kDa protein coded by a single gene, LGALS3, located on chromosome 14. LGALS3 is composed of six exons and five introns, spanning a total of⁓ 17 kilobases (Fig. 1A). Exons IV to VI encode for the C-terminal domain containing the carbohydrate recognition domain (CRD). Exon III and 18 bp of exon II encode for a long and flexible N-terminal domain that contains sites for serine phosphorylation and other determinants important for the nonclassical secretion of the protein. Because of the presence of an N-terminal domain adjacent to the CRD, galectin-3 is classified as a chimera-type galectin.
影响因子：
56.9
作者：
Partridge, EA;Le Roy, C;Dennis, JW
通讯作者：
Dennis, JW
影响因子：
4.8
作者：
Argueso, Pablo;Guzman-Aranguez, Ana;Panjwani, Noorjahan
通讯作者：
Panjwani, Noorjahan
影响因子：
4
作者：
Saravanan, Chandrassegar;Liu, Fu-Tong;Panjwani, Noorjahan
通讯作者：
Panjwani, Noorjahan