Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches
Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches
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DOI：
10.1016/j.gde.2016.04.003
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发表时间：
2016-06-01
影响因子：
4
通讯作者：
Neuzil, Jiri
中科院分区：
文献类型：
--
作者：
Berridge, Michael V.;McConnell, Melanie J.;Neuzil, Jiri
目前的教条认为，基因是单个哺乳动物细胞的属性，并在细胞分裂期间在子细胞之间进行分配。然而，相当出乎意料的是，最近的研究已经证明了线粒体和线粒体DNA在几种哺乳动物细胞培养系统中的水平细胞间转移。此外，线粒体DNA转移发生在体内的明确证据现已公布。虽然这些研究显示了线粒体DNA在病理环境中的水平转移，但细胞间线粒体转移也可能是在发育和组织稳态中发挥作用的基本生理过程。
Current dogma holds that genes are the property of individual mammalian cells and partition between daughter cells during cell division. However, and rather unexpectedly, recent research has demonstrated horizontal cell-to-cell transfer of mitochondria and mitochondrial DNA in several mammalian cell culture systems. Furthermore, unequivocal evidence that mitochondrial DNA transfer occurs in vivo has now been published. While these studies show horizontal transfer of mitochondrial DNA in pathological settings, it is also possible that intercellular mitochondrial transfer is a fundamental physiological process with a role in development and tissue homeostasis.