Lack of Effect of Moderate Hypothermia on Brain Tissue Oxygenation after Acute Intracranial Hypertension in Pigs
Lack of Effect of Moderate Hypothermia on Brain Tissue Oxygenation after Acute Intracranial Hypertension in Pigs
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DOI：
10.1089/neu.2007.0433
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发表时间：
2010-02-01
影响因子：
4.2
通讯作者：
Jiang, Ji-Yao
中科院分区：
文献类型：
--
作者：
Bao, Ying-Hui;Liang, Yu-Min;Jiang, Ji-Yao
在这项研究中，我们探讨了亚低温对急性颅内高压后的脑组织氧合的影响。20头体重4-6 kg的健康幼年小型猪随机分为两组：常温组（n=10）和亚低温组（n=10）。用丙泊酚（4 mg/kg）静脉麻醉动物，插入气管内导管，并开始机械通气。所有动物均经左侧额叶注入自体动脉血，建立急性脑内血肿和颅内高压（颅内压[ICP]> 40 mm Hg）。在注射血液后30分钟开始冷却，并通过使用冰浴和冰袋实现。在低温组中，脑温降至33-34 ℃。正常体温组的脑温维持在37 +/- 0.38 ℃。连续监测颅内压（ICP）、脑灌注压（CPP）、脑组织氧分压（PbrO 2）、脑组织二氧化碳分压（PbrCO 2）和脑组织pH值（pH（br））3 h。与常温组比较，低温组ICP值明显降低，CPP明显改善（p
In this study, we explored the effect of moderate hypothermia on brain tissue oxygenation following acute intracranial hypertension in micropigs. Twenty healthy juvenile micropigs weighting 4-6 kg were randomized into two groups: a normothermia group (n=10) and a moderate hypothermia group (n=10). The animals were intravenously anesthetized with propofol (4mg/kg), an endotracheal tube was inserted, and mechanical ventilation was begun. Autologous arterial blood was injected into the left frontal lobe to establish acute intracerebral hematoma and intracranial hypertension (intracranial pressure [ICP]>40mm Hg) in all animals. Cooling was initiated at 30min after injection of the blood, and was achieved via the use of an ice bath and ice packs. In the hypothermia group, the brain temperature decreased to 33-34 degrees C. Brain temperature was maintained at 37 +/- 0.38 degrees C in the normothermia group. The ICP, cerebral perfusion pressure (CPP), brain tissue oxygen pressure (PbrO2), brain tissue carbon dioxide pressure (PbrCO2), and brain tissue pH value (pH(br)) were continuously monitored for 3 h in all animals. Compared to normothermia group, ICP values significantly decreased and CPP markedly improved in the hypothermia group (p