THE RELATIONSHIP BETWEEN BASAL-CELL EPITHELIOMA AND SEBORRHEIC KERATOSIS - A STUDY OF 60 CASES
THE RELATIONSHIP BETWEEN BASAL-CELL EPITHELIOMA AND SEBORRHEIC KERATOSIS - A STUDY OF 60 CASES
复制标题
DOI：
10.1111/j.1524-4725.1994.tb03201.x
复制
发表时间：
1994-11-01
期刊：
影响因子：
--
通讯作者：
RENDON, M
中科院分区：
文献类型：
--
作者：
RAO, BK;FREEMAN, RG;RENDON, M
背景。脂溢性角化病是一种罕见的皮肤肿瘤。我们报告60例脂溢性角化病合并基底细胞上皮瘤的病例。报告基底细胞上皮瘤与脂溢性角化病的关系，并讨论脂溢性角化病发生恶性变化的可能性。本文报告脂溢性角化病合并基底细胞上皮瘤60例。组织用中性缓冲福尔马林固定，处理后用标准苏木精和伊红染色。组织学检查显示脂溢性角化病与基底细胞上皮瘤有关。基底细胞上皮瘤在大多数病例（40/60）中伴有脂溢性角化病，并且似乎代表同一肿瘤的一部分。其余病例（20/60）两肿瘤相邻。脂溢性角化病的恶性改变是有争议的。我们建议脂溢性角化病的组织学评估，特别是当炎症或不典型的外观。这不应该作为病理评估或治疗每一个脂溢性角化病的授权，尽管它是潜在的恶性。
BACKGROUND. Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen.OBJECTIVE. To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis.METHODS. Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques.RESULTS. Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60).CONCLUSION. Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.