Genomic approaches to economic trait loci and tissue expression profiling: application to muscle biochemistry and beef quality
Genomic approaches to economic trait loci and tissue expression profiling: application to muscle biochemistry and beef quality
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DOI：
10.1016/s0309-1740(03)00020-2
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发表时间：
2004-01-01
期刊：
影响因子：
7.1
通讯作者：
Hocquette, JF
中科院分区：
文献类型：
--
作者：
Eggen, A;Hocquette, JF
遗传和环境因素深刻地改变动物的表型。如今，基因组学可以对基因特征（结构基因组学）和表达（功能基因组学）进行大规模分析。基因组作图、比较基因组学以及数量性状基因座和多态性的鉴定是积极研究的主题，以便更好地了解结构和多态性。基因的功能。使用 DNA 微阵列和蛋白质组学进行基因表达谱分析对于研究控制最终生物学功能的调控事件具有广阔的前景。这些新方法与经典遗传学和肌肉生物化学相结合形成综合生物学，将带来对复杂特征和生理过程的更好理解。对于牛来说，肉类科学的主要应用可能是：(1) 鉴定质量性状（例如嫩度）的新预测因子，(2) 通过生产系统（营养水平、生长路径、草饲）监测牛肉质量（包括可追溯性），以及 (3) 改进动物选择（标记和基因辅助选择），其中也可能包括质量性状。 (C) 2003 Elsevier Ltd. 保留所有权利。
Genetic and environmental factors profoundly alter the phenotypes of animals. Nowadays, genomics allows large-scale analysis of gene characteristics (structural genomics) and expression (functional genomics). Genome mapping, comparative genomics and identification of quantitative trait loci and polymorphisms are the subject of active investigation to gain a better knowledge of the structure and. function of genes. Gene expression profiling using DNA microarrays and proteomics holds great promise for the study of regulatory events which control the final biological functions. Combined with classical genetics and muscle biochemistry to form an integrative biology, these new approaches will bring a better understanding of complex traits and physiological processes. Major applications in meat science could be, for cattle, (1) the identification of new predictors of quality traits (for instance, tenderness), (2) the monitoring of beef quality (including traceability) through the production systems (nutrition level, growth path, grass-feeding), and (3) the improvement of animal selection (markers and gene assisted selection) which may also include quality traits. (C) 2003 Elsevier Ltd. All rights reserved.