Epstein-Barr Virus Negativity among Individuals Older than 60 Years Is Associated with HLA-C and HLA-Bw4 Variants and Tonsillectomy
Epstein-Barr Virus Negativity among Individuals Older than 60 Years Is Associated with HLA-C and HLA-Bw4 Variants and Tonsillectomy
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DOI：
10.1128/jvi.00169-13
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发表时间：
2013-06-01
影响因子：
5.4
通讯作者：
Hess, Christoph
中科院分区：
文献类型：
--
作者：
Durovic, Bojana;Gasser, Olivier;Hess, Christoph
EB病毒（EBV）感染率接近95%的成年人。在剩下的大约5%的人中，赋予保护作用的因素仍然未知。在一项探索性研究中，我们评估了年龄>60岁的17名EBV阴性和39名EBV阳性健康个体的免疫遗传因素和扁桃体切除术。HLA基因型分析显示EBV阴性与HLA-C-35 T/T和/或HLA-Bw 4等位基因的存在相关。此外，EBV阴性供体比EBV阳性供体更常出现扁桃体切除术史。
Epstein-Barr virus (EBV) infects similar to 95% of the adult population. The factors that confer protection in the remaining similar to 5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 years. Analyses of HLA genotypes revealed an association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4 alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more often than EBV-positive donors.