CONGENITAL HEART DISEASE IN 56,109 BIRTHS - INCIDENCE AND NATURAL HISTORY
CONGENITAL HEART DISEASE IN 56,109 BIRTHS - INCIDENCE AND NATURAL HISTORY
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DOI：
10.1161/01.cir.43.3.323
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发表时间：
1971-01-01
期刊：
影响因子：
37.8
通讯作者：
BERENDES, HW
中科院分区：
文献类型：
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作者：
MITCHELL, SC;KORONES, SB;BERENDES, HW
在一项对56109名新生儿进行的前瞻性研究中，457名年轻人被发现患有先天性心脏病。总发病率为8.14/1000，黑人为8.0/1000，白人为8.3/1000。已经为每个患者确定了一个特定的病变，并给出了每一类患者、死产、新生儿死亡、婴儿死亡、儿童死亡和幸存者的病变频率。死产的尸检率为93%，新生儿死亡的尸检率为%，28日龄后死亡的尸检率为76%。在那些被归类为明确患有先天性心脏病的人中，93%的人已经接受了儿科心脏病专家的检查。272例幸存者的平均随访时间为3年。存活超过6个月的室间隔缺损患者中，35%的患者的病变自发闭合；法洛四联症患者中有一半的幸存者是“不典型的”，黑人和白人的人数基本相等，他们的所有类型的主动脉缩窄与研究人群一致，其中47%是黑人，53%是白人。
Within a prospective study of 56,109 total births, 457 youngsters have been found to have congenital heart disease. The overall incidence is 8.14/1000 total births, 8.0/1000 for the Negro and 8.3/1000 for the white. A specific lesion has been identified for each patient and lesion frequencies given for each class of patient, stillbirth, neonatal death, infant death, childhood death, and survivors. The percentage of autopsies was 93% in the stillbirths, 89% in the neonatal deaths, and 76% for those dying after 28 days of age. Of those classified as having definite congenital heart disease, 93% have been examined by a pediatric cardiologist. The average follow-up time for the 272 survivors is 3 years. Thirty-five per cent of patients with ventricular septal defect surviving more than 6 months had their lesion close spontaneously; one-half of the survivors with tetralogy of Fallot were "atypical," and essentially equal numbers of blacks and whites had all types of coarctation of the aorta in line with the study population, which is 47% black and 53% white.