Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue: December 2020-August 2021.
Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue: December 2020-August 2021.
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北美博彩场所个人中 COVID-19 发病率、疫苗接种、血清峰值 IgG 和病毒中和潜力随时间的变化：2020 年 12 月至 2021 年 8 月。
DOI：
10.1097/jom.0000000000002617
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发表时间：
2022
影响因子：
3.2
通讯作者：
Redlich,CarrieA
中科院分区：
文献类型：
--
作者：
Wisnewski,AdamV;Cantley,Linda;CampilloLuna,Julian;Liu,Jian;Smith,RichardF;Hager,Kelly;Redlich,CarrieA
目的评估游戏/娱乐行业工作人员的COVID-19病例和疫苗反应。方法通过问卷调查，提供职业危险因素、人口统计学、COVID-19病史、疫苗接种情况等详细信息。酶联免疫吸附法测定血清抗病毒抗体和中和能力。结果共有550人参与，其中n= 228人（41.5%）返回随访。至少71%的参与者在疫苗可用的8个月内完全接种了疫苗，COVID-19的发病率也随之下降。血清抗刺突IgG水平和中和能力与COVID-19病史和疫苗类型显著相关（P< 0.001），但与职业危险因素无关，并在5个月内下降（平均36%）。很少有疫苗无反应（n= 12）和“突破性”感染（n= 1）被注意到。结论接种新型冠状病毒肺炎疫苗可显著降低感染；然而，随着时间的推移，个体体液反应有所不同并显著下降。
ObjectiveThis study aims to evaluate COVID-19 cases and vaccine responses among workers in the gaming/entertainment industry.MethodsParticipants provided detailed information on occupational risk factors, demographics, COVID-19 history, and vaccination status through questionnaire. Enzyme-linked immunosorbent assays were used to measure serum antiviral antibodies and neutralizing capacity.ResultsFive hundred-fifty individuals participated with n= 228 (41.5%) returning for follow-up. At least 71% of participants were fully vaccinated within 8 months of vaccine availability and COVID-19 rates declined concomitantly. Serum anti–spike IgG levels and neutralizing capacity were significantly (P< 0.001) associated COVID-19 history and vaccine type, but not occupational risk factors, and declined (on average 36%) within 5 months. Few vaccine nonresponders (n= 12) and “breakthrough” infections (n= 1) were noted.ConclusionsCOVID-19 vaccination was associated with a marked decrease in infections; however, individual humoral responses varied and declined significantly over time.