Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging
Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging
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DOI：
10.1016/s0301-5629(00)00279-9
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发表时间：
2001-01-01
影响因子：
2.9
通讯作者：
Crum, LA
中科院分区：
文献类型：
--
作者：
Vaezy, S;Shi, XG;Crum, LA
高强度聚焦超声（HIFU）和传统的B型超声（US）成像同步开发的系统，用于实时可视化的HIFU治疗。该系统在猪肝中进行了体内测试。HIFU应用导致焦点处出现高回声斑点，在停止HIFU暴露后逐渐消失。高回声斑点出现所需的HIFU暴露的持续时间与HIFU强度呈负相关。在原位，在肝脏中产生高回声点所需的阈值强度为970 W/cm（2）。在该HIFU剂量下，未观察到立即的细胞损伤，为预处理靶向提供了可能性。实时可视化方法用于盆腔内血管活动性出血的止血，允许靶向和监测成功治疗。实时超声成像可以为图像引导的HIFU治疗提供有用的工具。电子邮件：adasi@u.washington.edu）（C）2001年世界医学和生物学超声联合会。
High-intensity focused ultrasound (HIFU) and conventional B-mode ultrasound (US) imaging were synchronized to develop a system for real-time visualization of HIFU treatment. The system was tested in vivo in pig liver. The HIFU application resulted in the appearance of a hyperechoic spot at the focus that faded gradually after cessation of HIFU exposure. The duration of HIFU exposure needed for a hyperechoic spot to appear, was inversely related to the HIFU intensity. The threshold intensity required to produce a hyperechoic spot in liver in < is was 970 W/cm(2), in situ. At this HIFU dose, no immediate cellular damage was observed, providing a potential for pretreatment targeting. The real-time visualization method was used in hemostasis of actively bleeding internal pelvic vessels, allowing targeting and monitoring of successful treatment. Real-time US imaging may provide a useful tool for image-guided HIFU therapy. CE-mail: adasi@u.washington.edu) (C) 2001 World Federation for Ultrasound in Medicine & Biology.