The time course of incentive processing in anticipatory and consummatory anhedonia
The time course of incentive processing in anticipatory and consummatory anhedonia
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预期性和完成性快感缺乏中激励处理的时间过程
DOI：
10.1016/j.jad.2018.05.053
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发表时间：
2018-10-01
影响因子：
6.6
通讯作者：
Zheng, Ya
中科院分区：
文献类型：
--
作者：
Chen, Youmei;Xu, Jing;Zheng, Ya
背景：快感缺乏，即体验快乐的能力降低，长期以来被认为是抑郁症和精神分裂症的主要症状。最近的证据表明，快感缺失不是一个单一的结构，而是由预期成分和完成成分组成，这是由时间体验的快乐量表（TEPS）。目前的事件相关电位研究检查了预期和完善方面的快感缺乏的电生理基础，如TEPS在非临床样本中所评估的。记录了预期-快感缺失（ANT）组、完成-快感缺失（CON）组、对照组（CNT）根据TEPS评分从大样本中选出。在预期阶段，ANT相对于CON组表现出减少的线索P3，在完成阶段，积极反馈相关负性（FRN）较低，反馈P3（fb-P3）变钝。此外，相关性结果揭示了预期性快感缺失和完全性快感缺失之间的分离，这是以一种意想不到的方式发生的，即较高水平的预期性快感缺失与fb-P3振幅的降低相关，而较高水平的完全性快感缺失与提示P3和FRN振幅的增强相关。局限性：每组的样本量相对较小。预期性和完成性快感缺失的TEPS测量可能是由异常的动机突显性，这是代表的线索P3在预期阶段和FRN和fb-P3在奖励加工的完成阶段。
Background: Anhedonia, the reduced capacity to experience pleasure, has long been regarded as a cardinal symptom in depression and schizophrenia. Recent evidence highlights that anhedonia is not a single construct but consists of an anticipatory component and a consummatory component, which is captured by the Temporal Experience of Pleasure Scale (TEPS). The current event-related potential study examined the electrophysiological underpinnings of anticipatory and consummatory aspects of anhedonia as assessed by the TEPS in a non-clinical sample.Methods: EEG was recorded during both anticipatory and consummatory phases of incentive processing in an anticipatory-anhedonia (ANT) group, a consummatory-anhedonia (CON) group, and a control (CNT) group selected from a large sample based on their TEPS scores.Results: The ANT relative to the CON group exhibited a reduced cue-P3 during the anticipatory phase, a less positive feedback-related negativity (FRN) and a blunted feedback P3 (fb-P3) during the consummatory phase. Moreover, correlation results revealed a dissociation between anticipatory and consummatory anhedonia, which occurred in an unexpected way such that higher levels of anticipatory anhedonia were associated with reduced fb-P3 amplitudes whereas higher levels of consummatory anhedonia with enhanced cue-P3 and FRN amplitudes.Limitation: The sample size for each group was relatively small.Conclusions: Anticipatory and consummatory anhedonia as measured by the TEPS might be driven by abnormal motivational salience, which was represented by the cue-P3 during the anticipatory phase and the FRN and fb-P3 during the consummatory phase of incentive processing.