Maternal Nutrition and Glycaemic Index during Pregnancy Impacts on Offspring Adiposity at 6 Months of Age--Analysis from the ROLO Randomised Controlled Trial.
Maternal Nutrition and Glycaemic Index during Pregnancy Impacts on Offspring Adiposity at 6 Months of Age--Analysis from the ROLO Randomised Controlled Trial.
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DOI：
10.3390/nu8010007
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发表时间：
2016-01-04
期刊：
影响因子：
5.9
通讯作者：
McAuliffe FM
中科院分区：
文献类型：
--
作者：
Horan MK;McGowan CA;Gibney ER;Byrne J;Donnelly JM;McAuliffe FM
儿童肥胖与成人肥胖和代谢疾病的风险增加有关。怀孕期间的饮食和生活方式会影响胎儿的编程；然而，特定饮食成分（包括低血糖指数（GI））的影响仍然很复杂。我们研究了母亲低 GI 饮食干预对 6 个月时后代肥胖的影响，并探讨了妊娠期饮食和生活方式因素以及 6 个月时婴儿身体成分之间的关联。 ROLO 研究对来自对照组 (n = 142) 和干预组 (n = 138) 的 280 对 6 个月大的婴儿和母亲进行了分析，这些婴儿和母亲在怀孕期间接受了低 GI 饮食建议。调查问卷（食物日记和生活方式）在怀孕期间完成，随后在产后 6 个月完成母亲生活方式和婴儿喂养调查问卷。在整个怀孕期间和产后 6 个月对母亲人体测量值以及婴儿人体测量值进行测量。对照组和干预组之间 6 个月婴儿肥胖情况没有发现差异。母亲孕期三期的 GI、孕期二期的饱和脂肪以及孕期一期和孕期三期的钠摄入量与后代肥胖呈正相关，而孕期二期和孕期三期的维生素 C 摄入量则呈负相关。总之，我们观察到母亲怀孕期间的膳食摄入量和 GI 以及后代 6 个月大时的肥胖之间存在关联。
Childhood obesity is associated with increased risk of adult obesity and metabolic disease. Diet and lifestyle in pregnancy influence fetal programming; however the influence of specific dietary components, including low glycaemic index (GI), remains complex. We examined the effect of a maternal low GI dietary intervention on offspring adiposity at 6 months and explored the association between diet and lifestyle factors in pregnancy and infant body composition at 6 months. 280 6-month old infant and mother pairs from the control (n = 142) and intervention group (n = 138), who received low GI dietary advice in pregnancy, in the ROLO study were analysed. Questionnaires (food diaries and lifestyle) were completed during pregnancy, followed by maternal lifestyle and infant feeding questionnaires at 6 months postpartum. Maternal anthropometry was measured throughout pregnancy and at 6 months post-delivery, along with infant anthropometry. No difference was found in 6 months infant adiposity between control and intervention groups. Maternal trimester three GI, trimester two saturated fats and trimester one and three sodium intake were positively associated with offspring adiposity, while trimester two and three vitamin C intake was negatively associated. In conclusion associations were observed between maternal dietary intake and GI during pregnancy and offspring adiposity at 6 months of age.