Application of in vivo stain of methylene blue as a diagnostic aid in the early detection and screening of oral squamous cell carcinoma and precancer lesions.
Application of in vivo stain of methylene blue as a diagnostic aid in the early detection and screening of oral squamous cell carcinoma and precancer lesions.
复制标题
DOI：
10.1016/s1726-4901(08)70048-0
复制
发表时间：
2007-11-01
期刊：
影响因子：
--
通讯作者：
Fong, Yao
中科院分区：
文献类型：
--
作者：
Chen, Ya-Wei;Lin, Jiun-Sheng;Fong, Yao
背景技术背景：通过筛查具有高风险因素的个体来早期检测口腔恶性或癌前病变，可以确定应该接受治疗的候选人，以防止癌症进展并降低患者死亡率。在诊断工具中，体内染色被认为是一种简单、廉价且相当敏感的方法。方法：本研究通过亚甲基蓝染色对58例疑似口腔恶性或癌前病变的患者进行检查。亚甲蓝摄取的结果进行了比较，同时活检这些病变。结果：经病理证实的癌前病变和癌为筛查的阳性对象，良性上皮性病变为筛查的阴性对象，其敏感性为90%，特异性为69%，阳性预测值为74%，阴性预测值为87%。我们认为，亚甲蓝染色是一个有用的诊断辅助，在一个大型的，以社区为基础的口腔癌筛查计划的高风险个人。
BACKGROUND: Early detection of oral malignant or precancerous lesion by screening individuals with high-risk factors may identify candidates who should receive treatment to prevent cancer progression and reduce patient mortality. Among the diagnostic tools, in vivo staining is advocated as a simple, inexpensive, and fairly sensitive method.METHODS: The present study involved the examination of 58 patients suspected of having oral malignant or precancerous lesions by methylene blue staining. The results of methylene blue uptake were compared with a simultaneous biopsy of these lesions. The pathologically confirmed precancers and cancers were the positive targets of this screening, while benign epithelial lesions were sorted as negative subjects of screening.RESULTS: The results revealed sensitivity of 90%, specificity of 69%, positive predictive value of 74%, and negative predictive value of 87%.CONCLUSION: We consider that methylene blue staining is a useful diagnostic adjunct in a large, community-based oral cancer screening program for high-risk individuals.